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A three-component cycloaddition of alkyl trifluorodiazoethane for the synthesis of trifluoromethylated isoxazolines

Chemistry of Heterocyclic Compounds, 2023
Jingwen Xu   +4 more
semanticscholar   +1 more source

Isoxazolines and isoxazoles as factor Xa inhibitors

Bioorganic & Medicinal Chemistry Letters, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ruth R. Wexler   +7 more
openaire   +4 more sources

Synthesis of Isoxazoline-Substituted Symmetrical Diketopiperazines

Synlett, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Marilyn M. Olmstead   +2 more
openaire   +3 more sources

Copper-Mediated Domino Cyclization/Trifluoromethylation of Propargylic N-Hydroxylamines: Synthesis of 4-Trifluoromethyl-4-isoxazolines.

Journal of Organic Chemistry, 2018
A Cu(OTf)2-mediated synthesis of trifluoromethylated 4-isoxazolines is described. In one step from readily available propargylic N-hydroxylamines, a domino 5-endo-dig cyclization, followed by trifluoromethylation, takes place to construct the 4 ...
Quan-Fu Wang, G. Tsui
semanticscholar   +1 more source

Synthesis, Antioxidant, and Antibacterial Activities of Two Novel Series of 3,5-Disubstituted Isoxazole Ether-Linked Isoxazolines and 3,5-Disubstituted Pyrazole Ether-Linked Isoxazolines Mediated by Chloramine-T

Russian journal of bioorganic chemistry, 2022
E. M. Saleh   +8 more
semanticscholar   +1 more source

Synthesis of 4-Isoxazolines via Visible-Light Photoredox-Catalyzed [3 + 2] Cycloaddition of Oxaziridines with Alkynes.

Organic Letters, 2017
A method for [3 + 2] cycloaddition of oxaziridines with alkynes to form 4-isoxazolines via visible-light photoredox catalysis is described. This method is a greener, atom-economical reaction that tolerates various functional groups and provides good to ...
Gwang Seok Jang   +3 more
semanticscholar   +1 more source

P(NMe2)3-Mediated Reductive (1 + 4) Annulation Reaction of Isatins with Nitroalkenes: An Access to Spirooxindolyl Isoxazoline N-Oxides and Their Corresponding Isoxazolines.

Journal of Organic Chemistry, 2017
The reductive (1 + 4) annulation reaction of isatins and substituted nitroalkenes mediated by a trivalent phosphorus reagent has been realized for the first time, providing easy access to spirooxindolyl isoxazoline N-oxides in moderate to excellent ...
Yiyi Liu   +3 more
semanticscholar   +1 more source

Access to Cyano-Containing Isoxazolines via Copper-Catalyzed Domino Cyclization/Cyanation of Alkenyl Oximes.

Journal of Organic Chemistry, 2017
A highly efficient copper-catalyzed cyclization/cyanation cascade of unactivated olefins bearing oximes is described. A variety of cyano-containing isoxazolines have been obtained in high yields with cheap Cu(NO3)2·3H2O as the catalyst and TMSCN as the ...
Fei Meng   +5 more
semanticscholar   +1 more source

Iron(III)-catalyzed selective N–O bond cleavage to prepare tetrasubstituted pyridines and 3,5-disubstituted isoxazolines from N-vinyl-α,β-unsaturated ketonitrones

, 2018
An iron(III)-catalyst controlled cyclization and selective N–O bond cleavage of N-vinyl-α,β-unsaturated nitrones has been achieved under mild conditions to access tetrasubstituted pyridines and 3,5-disubstituted isoxazolines in moderate to good yields ...
Chunhua Chen   +5 more
semanticscholar   +1 more source

A three-component approach to isoxazolines and isoxazoles under metal-free conditions.

Organic and biomolecular chemistry, 2019
A 1,3-dipolar cycloaddition of 2-methylquinoline, tert-butyl nitrite (TBN) and alkynes or alkenes for the synthesis of biheteroaryls containing both isoxazoline/isoxazole and quinoline motifs has been developed.
Dahan Wang   +3 more
semanticscholar   +1 more source

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