Results 11 to 20 of about 70,911 (234)

African dung beetle Onthophagus gazella Fabricius (Coleoptera: Scarabaeidae) esterase isozymes [PDF]

open access: goldBrazilian Journal of Biology, 2001
African beetles Onthophagus gazella from both sexes were analyzed by electrophoresis for an investigation of esterase isozymes using alpha-naphthyl propionate and methylumbelliferyl propionate as substrates. Only one of the esterases (Est.
MARTINS E., CONTEL E. P. B.
doaj   +2 more sources

Collateral metabolic vulnerabilities unveiled by loss of isozyme diversity in breast cancer [PDF]

open access: yesGenome Medicine
Background Loss of isozyme diversity (LID) refers to the selective dependency on a single isozyme following the functional collapse of its redundant counterparts, uncovering a metabolic vulnerability.
Rui Ding   +4 more
doaj   +2 more sources

The evolutionary conservation of eukaryotic membrane-bound adenylyl cyclase isoforms

open access: yesFrontiers in Pharmacology, 2022
The nine membrane-delimited eukaryotic adenylyl cyclases are pseudoheterodimers with an identical domain order of seven (nine) distinct subdomains. Bioinformatics show that the protein evolved from a monomeric bacterial progenitor by gene duplication and
Joachim E. Schultz
doaj   +1 more source

Quantitative and Qualitative Genetic Studies of Some Acacia Species Grown in Egypt

open access: yesPlants, 2020
The objective of the current work is to study the genetic differentiation between Acacia species growing in Egypt as plant genetic resources based on morphological, biochemical, and molecular markers.
Nader R. Abdelsalam   +3 more
doaj   +1 more source

EFEK PAPARAN GLUKOSA KONSENTRASI TINGGI TERHADAP PENINGKATKAN AKTIVITAS ISOZIM PROTEIN KINASE C (PKC)-ALPHA PADA KULTUR SEL STROMA PROSTAT

open access: yesJurnal Urologi Indonesia, 2014
OBJECTIVE: To prove that glucose treatment in human prostatic stromal cells (HPSC) culture would increase PKC alpha isozyme activity. MaterialS & Methods: Primary cultures of HPSC were obtained from patients with bladder outlet obstruction caused by ...
Basuki B Purnomo   +2 more
doaj   +1 more source

Evaluation of genetic variability in Algerian clover (Trifolium L.) based on morphological and isozyme markers

open access: yesCzech Journal of Genetics and Plant Breeding, 2015
Genetic variation within and among fifteen Trifolium species represented by 157 accessions was assessed using morphological and isozyme markers. Most of morphometric characters contributed to the discrimination of the species. No significant relationship
Imane MEDOUKALI   +2 more
doaj   +1 more source

Biochemical genetics in the Argentinean squid, Illex argentinus

open access: yesScientia Marina, 1998
Previously reported results on natural populations of the Argentinean squid, Illex argentinus, urged further studies using electrophoretically detectable loci. The muscles of 202 adult squids caught in the Argentinean Sea were examined.
B. Jérez, M. I. Roldan, C. Pla
doaj   +1 more source

Analysis of peroxidase isozymes and HPLC chromatographic study of paeoniflorin in Hangzhou white peony

open access: yes浙江大学学报. 农业与生命科学版, 2005
The peroxidase isozymes of Hangzhou white peony were isolated by polyacrylamide gel electrophoresis. Up to 2-5 active bands of peroxidase isozyme were observed in 13 lines after active dyeing, and the rate of relative migration was located in the range ...
SONG Qin   +3 more
doaj   +1 more source

Microwave assisted solvent-free mannich bases: synthesis, characterization and effects of these compounds on HCA I and HCA II isozymes

open access: yesMacedonian Journal of Chemistry and Chemical Engineering, 2021
Mannich bases (2a–d) of aromatic amines were synthesized by using a conventional microwave technique under solvent-free conditions and characterized by IR and NMR (1H and 13C) and elemental analysis.
Bülent Büyükkıdan   +5 more
doaj   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

open access: yesAngewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu   +16 more
wiley   +2 more sources

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