Results 11 to 20 of about 77,070 (295)

Downy mildew resistance and genetic variability in a wild rocket germplasm collection

Agronomy Journal, Volume 114, Issue 6, Page 3083-3095, November/December 2022., 2022
Abstract One hundred accessions of a “core collection” of Diplotaxis tenuifolia (L.) DC. and Eruca spp. were screened at seedling stage for resistance to downy mildew. Accessions tested at the seedling stage were assigned to 0–6 interaction phenotypes.
Paula S. Coelho, João M. Reis, Ana L. Pereira, Aliana Vairinhos, Violeta Lopes, José M. Leitão   +5 more
wiley   +1 more source

Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca, Andrea Angeli, Federico Ricci, Claudiu T. Supuran, Rosaria Gitto   +4 more
wiley   +1 more source

Isozymes of glycogen synthase [PDF]

FEBS Letters, 1984
Antisera to rat skeletal muscle glycogen synthase failed to recognize liver glycogen synthase by electroblot analysis. The antisera recognized the enzyme in skeletal muscle, heart, fat, kidney, and brain. The results support the hypothesis that there are at least two isozymes of glycogen synthase, and that most tissues contain a form similar or ...
Harvey R. Kaslow, David D. Lesikar
openaire   +3 more sources

Plasma alkaline phosphatase isozymes: Isolation and characterization of isozymes [PDF]

Biochimica et Biophysica Acta (BBA) - Enzymology, 1971
Abstract 1. 1. The two isozymes of alkaline phosphatase (orthophosphoric monoester phosphohydrolase, EC 3.1.3.1) detectable in human blood group O plasma have been separated from one another and isolated in a high state of purity. With p- nitrophenyl phosphate as substrate, the catalytic properties of the two isozymes appear to be the same
Aminoff, David, Austrins, Mikelis, Zolfaghari, S. P.   +2 more
openaire   +4 more sources

Retinal regions shape human and murine Müller cell proteome profile and functionality

Glia, Volume 71, Issue 2, Page 391-414, February 2023., 2023
Main Points We defined Müller cells heterogeneity in the macular and peripheral human retina. Signaling pathways shaping this glial heterogeneity include proteins important for interaction with vesicular secretion, extracellular matrix and cell adhesion.
Lew Kaplan, Corinne Drexler, Anna M. Pfaller, Santra Brenna, Kirsten A. Wunderlich, Andrea Dimitracopoulos, Juliane Merl‐Pham, Maria‐Theresa Perez, Ursula Schlötzer‐Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M. Hauck, Antje Grosche   +15 more
wiley   +1 more source

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Characterization of pig skeletal muscle transcriptomes in response to low temperature

Veterinary Medicine and Science, Volume 9, Issue 1, Page 181-190, January 2023., 2023
Low temperature changes the gene expression pattern and biological pathway in pig skeletal muscle. Under low temperature, biological pathways of lipid, amino acid, and carbohydrate metabolism; signal transduction; endocrine, immune, and nervous system; cardiovascular disease; infectious diseases caused by bacteria or viruses; and neurodegenerative ...
DongJie Zhang, Liang Wang, ShouZheng Ma, Hong Ma, Di Liu   +4 more
wiley   +1 more source

Plasma proteomic signature of decline in gait speed and grip strength

Aging Cell, Volume 21, Issue 12, December 2022., 2022
Several plasma proteins were associated with physical function decline in adults from middle to older age, including GDF‐15, pleiotrophin, and TIMP‐1 for gait speed decline, and CA III, CDON, and SMOC1 for grip strength decline. These novel proteomic biomarkers may by explored as future mechanisms and targets for age‐related functional decline ...
Xiaojuan Liu, Stephanie Pan, Vanessa Xanthakis, Ramachandran S. Vasan, Bruce M. Psaty, Thomas R. Austin, Anne B. Newman, Jason L. Sanders, Chenkai Wu, Russell P. Tracy, Robert E. Gerszten, Michelle C. Odden   +11 more
wiley   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, EarlyView., 2023
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source