Results 41 to 50 of about 79,895 (267)

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

Analysis of genetic diversity in the core collection of red clover (Trifolium pratense) with isozyme and RAPD markers [PDF]

Crop Breeding and Applied Biotechnology, 2008
The genetic diversity in the red clover USA core collection was measured by RAPD and isozyme markers,comparing different approaches of isozyme data analysis and comparing the results of RAPD with those of isozymes.
Paula Menna Barreto Dias, Viviane Falkembach Pretz, Miguel Dall’Agnol, Maria Teresa Schifino-Wittmann, Jose Angelo Zuanazzi   +4 more
doaj  

Studies on isozyme variation in marginal and central populations of Picea abies.

Hereditas, 2009
Two delimited populations of Picea abies, each comprising about 50 individuals have been analysed with regard to three different enzyme systems, esterase (EST), leucine-amino-peptidase (LAP) and acid phosphatase (PHOS).
P. Tigerstedt
semanticscholar   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Absence of an acid phosphatase isozyme locus as a marker candidate for true to typeness in woodland grape (Vitis vinifera L. ssp. sylvestris Gmelin)

OENO One, 2017
The quest and conservation of existing populations of woodland grape (Vitis vinifera L. ssp. sylvestris Gmelin), the supposed progenitor of the European grapevine (Vitis vinifera L. ssp.
Gizella Jahnke, Zóra Annamária Nagy, Gábor Koltai, Edit Hajdu, János Májer   +4 more
doaj   +1 more source

PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKCdelta and inactivates the oncogenic isozyme PKCvarepsilon [PDF]

Carcinogenesis, 2003
Protein kinase C (PKC) is a family of ten isozymes that play distinct and in some cases opposing roles in cell growth and survival. We recently reported that diamide, a diazene carbonyl derivative which oxidizes thiols to disulfides through addition/displacement reactions at the diazene bond, induces potent GSH-dependent inactivation of several PKC ...
Nancy E. Ward, Feng Chu, Catherine A. O’Brian   +2 more
openaire   +3 more sources

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Growth and Physiological Responses of Adenophora triphylla (Thunb.) A.DC. Plug Seedlings to Day and Night Temperature Regimes

Agronomy, 2018
Adenophora triphylla (Thunb.) A.DC., three-leaf lady bell, is an important medicinal plant used against cancers and obesity. It has been well-established that the temperature regime affects plant growth and development in many ways.
Ya Liu, Xiuxia Ren, Hai Kyoung Jeong, Hao Wei, Byoung Ryong Jeong   +4 more
doaj   +1 more source

Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase*[boxs]

Journal of Biological Chemistry, 2004
Three nitric-oxide synthase (NOS) isozymes play crucial, but distinct, roles in neurotransmission, vascular homeostasis, and host defense, by catalyzing Ca2+/calmodulin-triggered NO synthesis. Here, we address current questions regarding NOS activity and
E. Garcin, C. M. Bruns, S. J. Lloyd, D. Hosfield, Mauro Tiso, R. Gachhui, D. Stuehr, J. Tainer, E. Getzoff   +8 more
semanticscholar   +1 more source

Gut Microbiota‐Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High‐Altitude

Exploration, EarlyView.
Long‐term migration to high‐altitude areas can readily result in chronic high‐altitude diseases; however, effective prevention and treatment methods are currently lacking. This study employed a multi‐omics approach, integrating metagenomics and metabolomics, to discover and validate that the decreased abundance of Veillonella rogosae, Streptococcus ...
Yongqiang Zhou, Zhexin Ni, Jingjing Liu, Dezhi Sun, Pan Shen, Xi Chen, Gaofu Li, Zhijie Bai, Yangyi Hu, Ningning Wang, Rui Wang, Lina Guan, Yihao Wang, Xianglin Tang, Yungang Lu, Baokun He, Haitao Lu, Wei Zhou, Yue Gao   +18 more
wiley   +1 more source