Results 41 to 50 of about 69,433 (226)

Deserts, Rivers, Pools, and Billabongs: Water Features of the Nitrogenase Proteins, and their Functions

ChemBioChem, EarlyView.
In the protein surrounding the active site of nitrogenase there is a large anhydrous desert, traversed by two watercourses necessary for the enzyme to convert N2 to NH3. Various pools exist, but their water seems to be stagnant. This review examines the occurrence and function of water inside the protein that contains the catalytic site of the enzyme ...
Ian Dance
wiley   +1 more source

Variability among inbred lines and RFLP mapping of sunflower isozymes

Genetics and Molecular Biology, 2002
Eight isozyme systems were used in this study: acid phosphatase (ACP), alcohol dehydrogenase (ADH), esterase (EST), glutamate dehydrogenase (GDH), malate dehydrogenase (MDH), phosphoglucoisomerase (PGI), 6-phosphogluconate dehydrogenase (PGD), and ...
Carrera Alicia D., Pizarro G., Poverene M., Feingold S., León A.J., Berry S.T.   +5 more
doaj  

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Microplastics in Agricultural Soil: Fate, Impacts, and Bioremediation by Earthworms

Journal of Plant Nutrition and Soil Science, EarlyView.
Microplastics enter the soil through various means, including the degradation of plastic film mulch, waste from cosmetics industries and municipalities, and the use of bioplastic seed coatings. These microplastics disrupt soil structure, microbial activity, enzyme function, and plant growth.
Sami ur Rehman, Mudassar Hussain, Federica De Castro, Michele Benedetti, Alessio Aprile, Francesco Paolo Fanizzi   +5 more
wiley   +1 more source

African dung beetle Onthophagus gazella Fabricius (Coleoptera: Scarabaeidae) esterase isozymes

Brazilian Journal of Biology
African beetles Onthophagus gazella from both sexes were analyzed by electrophoresis for an investigation of esterase isozymes using alpha-naphthyl propionate and methylumbelliferyl propionate as substrates. Only one of the esterases (Est.
E. MARTINS, E. P. B. CONTEL
doaj   +1 more source

How do eyespot resistance genes transferred into winter wheat breeding lines affect their yield?

Journal of Plant Protection Research, 2016
Eyespot can reduce yields, even up to 50%. There are four genetically characterized resistances in wheat varieties, controlled by: (1) the Pch1 gene, transferred from Aegilops ventricosa; (2) the Pch2 gene, originating from wheat variety Capelle Desprez;
Kwiatek Michał, Wiśniewska Halina, Korbas Marek, Gawłowska Magdalena, Belter Jolanta, Majka Maciej, Danielewicz Jakub   +6 more
doaj   +1 more source

Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors

ChemistryOpen, EarlyView.
This work investigates the selective inhibition of MAO enzymes by varying the substitution of electron‐withdrawing and donating groups on the phenyl rings of tetrahydropyridines (4 a–4 o). Compounds 4 l and 4 n exhibit promising IC50 values of 0.40±0.05 and 1.01±0.03 μM against MAO‐A and MAO‐B, respectively.
Obaid ur Rehman Khan, Bilal Ahmad Khan, Syeda Shamila Hamdani, Saquib Jalil, Peter A. Sidhom, Khalid Elfaki Ibrahim, Tarad Abalkhail, Jamshed Iqbal, Hatem Tallima, Tamer Shoeib, Mahmoud A. A. Ibrahim   +10 more
wiley   +1 more source

An Electrophoretic Study of LDH-Isozyme Distribution in Developing Embryonic and Adult Tissues of the Toad Bufo arabicus

Sultan Qaboos University Journal for Science, 2009
Lactate (LDH) dehydrogenases were studied by electrophoresis to investigate the possibility of isozymic differences in different  stages and organs of B. arabicus embryos, tadpoles and adults.
Intisar Ambusaidi, Taher Ba-Omar, Saif Al-Bahri, Aisha Al-Shihi   +3 more
doaj   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source