Results 61 to 70 of about 79,895 (267)
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo +5 more
wiley +1 more source
Journal of Lipid Research, 2007 Ferrous lipoxygenases seem to be activated through a feedback control mechanism via FA hydroperoxides generated from PUFAs by partially existing ferric lipoxygenases. However, during leukotriene synthesis, feedback activation of ferrous 5-lipoxygenase in
Tokuko Takajo +3 more
doaj
Glycolate oxidase isozymes are coordinately controlled by GLO1 and GLO4 in rice. [PDF]
PLoS ONE, 2012 Glycolate oxidase (GLO) is a key enzyme in photorespiratory metabolism. Four putative GLO genes were identified in the rice genome, but how each gene member contributes to GLO activities, particularly to its isozyme profile, is not well understood.
Zhisheng Zhang +7 more
doaj +1 more source
Vietnam Journal of Chemistry, EarlyView.Abstract The combination of cyclization reactions of thiadiazoles and benzothiazoles with Pd‐catalyzed cross‐coupling reactions provided a convenient synthesis of annulated, fluorinated and non‐fluorinated heterocycles, such as 1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐5‐ones, benzothiazolo[3,2‐a]pyridimidin‐4‐ones, benzothiazolo[2,3‐b]quinazolin‐12‐ones and ...
Peter Langer
wiley +1 more source
Journal of Neuroscience, 2000 We have identified a mechanism, mediated by the ε isozyme of protein kinase C (PKCε) in peripheral neurons, which may have a role in chronic inflammatory pain.
K. Aley +3 more
semanticscholar +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park +11 more
wiley +1 more source
Journal of Biological Chemistry, 1998 A novel manganese-dependent peroxidase (MnP) isozyme produced in manganese-free cultures ofBjerkandera sp. strain BOS55 was purified and characterized. The production of the enzyme was greatly stimulated by the exogenous addition of various physiological
T. Mester, J. Field
semanticscholar +1 more source
Evidence that mitochondrial isozymes are genetically less variable than cytoplasmic isozymes
Genetical Research, 1988 SummaryIt has been proposed that isoenzymes functioning within cell organelles (chloroplasts, mitochondria) are genetically less variable than their cytoplasmic counterparts, as a result either of constraints imposed by the need to cross organelle membranes or from the different and specialized nature of organelle metabolism.
David O. F. Skibinski, Robert D. Ward
openaire +3 more sources
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, EarlyView.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source
Minor Isozymes Tailor Yeast Metabolism to Carbon Availability
mSystems, 2019 Isozymes are enzymes that differ in sequence but catalyze the same chemical reactions. Despite their apparent redundancy, isozymes are often retained over evolutionary time, suggesting that they contribute to fitness.
Patrick H. Bradley +4 more
doaj +3 more sources