Results 151 to 160 of about 3,147 (209)

An approach to treat refractory catheter-related infections in patients undergoing peritoneal dialysis: tunnel-reconstruction operation. [PDF]

open access: yesRen Fail
Tian J   +11 more
europepmc   +1 more source

Structural and functional studies of mycobacterial IspD enzymes

open access: yesActa Crystallographica Section D: Biological Crystallography, 2011
A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize isopentenyl diphosphate via the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway rather than the classical mevalonate pathway found in humans.
Sherry L Mowbray   +2 more
exaly   +7 more sources

Identification and validation of a novel lead compound targeting 4-diphosphocytidyl-2-C-methylerythritol synthetase (IspD) of mycobacteria

open access: yesEuropean Journal of Pharmacology, 2012
Tuberculosis is a serious threat to world-wide public health usually caused in humans by Mycobacterium tuberculosis (M. tuberculosis). It exclusively utilizes the methylerythritol phosphate (MEP) pathway for biosynthesis of isopentenyl diphosphate (IPP ...
Peng Gao, Jianzhou Meng, Chunling Xiao
exaly   +2 more sources

ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment [PDF]

open access: yesPeritoneal Dialysis International, 2016
Abstract Peritonitis is a common and serious complication of peritoneal dialysis (PD). Although less than 5% of peritonitis episodes result in death, peritonitis is the direct or major contributing cause of death in around 16% of PD patients (1-6).
Beth Piraino, David Johnson, Eric Goffin
exaly   +8 more sources

Structure based de novo design of IspD inhibitors as anti-tubercular agents [PDF]

open access: yesNature Precedings, 2012
Tuberculosis is one of the leading contagious diseases, caused by Mycobacterium tuberculosis. Despite improvements in anti-tubercular agents, it remains one of the most prevalent infectious diseases worldwide, responsible for a total of 1.6 million ...
Venkata Krishnan Ramaswamy
exaly   +2 more sources

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