Results 81 to 90 of about 7,686 (214)

Structural and functional studies of mycobacterial IspD enzymes

Acta Crystallographica Section D Biological Crystallography, 2011
A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize isopentenyl diphosphate via the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway rather than the classical mevalonate pathway found in humans. As part of a structure-based drug-discovery program against tuberculosis, IspD, the enzyme that carries out the ...
Björkelid, Christofer, Bergfors, Terese, Henriksson, Lena M., Stern, Ana Laura, Unge, Torsten, Mowbray, Sherry L., Jones, T. Alwyn   +6 more
openaire   +4 more sources

Early Instrumental Weather Observations From Ukraine: The ClimUAsd‐Stn.v2 Dataset, 1808–1880

Geoscience Data Journal, Volume 13, Issue 1, January 2026.
The ClimUAsd‐stn.v2 dataset, containing instrumental sub‐daily meteorological observations (primarely air temperature and atmospheric pressure) recorded between 1808 and 1880 at twelve meteorological stations located within the territory of modern Ukraine, is presented.
Olesya Skrynyk, Jürg Luterbacher, Rob Allan, Vladyslav Sidenko, Kateryna Saloid, Elena Xoplaki, Oleg Skrynyk, Volodymyr Osadchyi   +7 more
wiley   +1 more source

The Structure, Kinematics and Physical Properties of the Molecular Gas in the Starburst Nucleus of NGC 253 [PDF]

, 2004
We present 5.2" x 2.6" resolution interferometry of CO J=1-0 emission from the starburst galaxy NGC 253. The high spatial resolution of these new data, in combination with recent high resolution maps of 13CO, HCN and near-infrared emission, allow us for ...
Flower D. R., Garcia-Burillo S., Henkel C., James M. Jackson, Mauersberger R., Omar Yam, Sofue Y., Sorai K., Stutzki J., Timothy A. D. Paglione, Tomoka Tosaki   +10 more
core   +2 more sources

Evolving Practices in Prenatal Open Spinal Dysraphism: A Global Survey of Selection Criteria, Surgical Techniques, and Diagnostic Trends

Prenatal Diagnosis, Volume 46, Issue 1, Page 75-83, January 2026.
ABSTRACT Objective To provide an updated overview of international clinical practice in prenatal repair of open spinal dysraphism (OSD), focusing on evolving eligibility criteria, surgical techniques, and diagnostic standards. Methods A structured online survey was distributed to 83 fetal surgery centers worldwide.
Corinna Keil, Noemi Wiora, Eyal Krispin, Anita Windhorst, Roland Axt‐Fliedner, Ivonne Bedei   +5 more
wiley   +1 more source

Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids [PDF]

, 2016
Background De novo production of multi-hydroxylated diterpenoids is challenging due to the lack of efficient redox systems. Results In this study a new reductase/ferredoxin system from Streptomyces afghaniensis (AfR·Afx) was identified, which allowed ...
Bernhard Loll, Christian Görner, Frank Wallrapp, Martin Haslbeck, Patrick Schrepfer, Thomas Brück, Veronika Redai, Wolfgang Eisenreich   +7 more
core   +3 more sources

Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice

FEBS Open Bio, 2014
CRISPR/Cas9 technology is a highly promising genome editing tool in the mouse, potentially overcoming the costs and time required for more traditional gene targeting methods in embryonic stem (ES) cells.
Angus Yiu-fai Lee, Kevin C. Kent Lloyd
doaj   +1 more source

Challenges in optimizing tacrolimus therapy in patients treated with rifampin: A case series

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3542-3548, December 2025.
Tacrolimus is a cornerstone immunosuppressant in transplantation medicine with a narrow therapeutic window. Drug–drug interactions with strong CYP3A4 and P‐glycoprotein modulators, such as rifampin and azole antifungals, significantly alter tacrolimus exposure and complicate therapy. Two transplant cases illustrates the impact of rifampin on tacrolimus
Jeroen P. A. Houwen, Aurelia H. M. de Vries Schultink, Bas J. M. Peters, Dieuwertje Ruigrok, Rob H. J. Schönwetter, Esther V. Uijtendaal, Maaike A. Sikma   +6 more
wiley   +1 more source

FFTPL: An Analytic Placement Algorithm Using Fast Fourier Transform for Density Equalization [PDF]

, 2013
We propose a flat nonlinear placement algorithm FFTPL using fast Fourier transform for density equalization. The placement instance is modeled as an electrostatic system with the analogy of density cost to the potential energy.
Chang, Chin-Chih, Chen, Pengwen, Cheng, Chung-Kuan, Huang, Dennis Jen-Hsin, Lu, Jingwei, Sha, Lu, Teng, Chin-Chi   +6 more
core  

Prediction of DC Breakdown Strength for Polymer Nanocomposite Based on Energy Depth of Trap

Energies
Understanding the role of carrier traps in the determination of dielectric breakdown of polymer nanocomposite would yield a novel method for the estimation of breakdown strength of the material.
Xiaohu Qi, Jian Guan, Xuri Xu, Zhen Zhang, Chuanyun Zhu, Chenyi Guo, Qifeng Shang, Yu Gao   +7 more
doaj   +1 more source

A child of congenital muscular dystrophy-dystroglycanopathy with homozygous missense variation in exon 3 of the ISPD Gene: A rare case from Odisha

Advanced Biomedical Research, 2020
Dystroglycanopathy is a type of congenital muscular dystrophy caused by mutations causing defective glycosylation of a dystrophin-associated glycoprotein, dystroglycan and as such is a very rare disease entity.
Sebaranjan Biswal, Debasish Panigrahi, Nirmal Kumar Mohakud, Manoj Kumar, Natabara Swain   +4 more
doaj   +1 more source