Results 101 to 110 of about 29,611 (279)
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
ISR volume 26 issue 4 Cover and Back matter [PDF]
, 1992 Hatza Othokh, Iton Rlshml
openalex +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
HIV Medicine, EarlyView.Abstract Introduction Long‐acting injectable antiretroviral therapy (ART) with Cabotegravir (CAB) and Rilpivirine (RPV) offers an alternative to daily oral regimens, improving adherence and patient satisfaction. However, its impact on body composition and metabolism remains underexplored.
Andrea De Vito +13 more
wiley +1 more source
The integrated stress response in neurodegenerative diseases
Molecular NeurodegenerationThe integrated stress response (ISR) is a conserved network in eukaryotic cells that mediates adaptive responses to diverse stressors. The ISR pathway ensures cell survival and homeostasis by regulating protein synthesis in response to internal or ...
Maria Astrid Bravo-Jimenez +2 more
doaj +1 more source
International Journal of Dental Hygiene, EarlyView.ABSTRACT Objective To evaluate the incomplete success rate (ISR) of non‐surgical periodontal therapy (NSPT) performed by registered dental hygienists, considering periodontitis staging and grading and multiple tooth‐ and patient‐level factors. Methods Data from patients with periodontitis treated by registered dental hygienists at the University of ...
Matteo Serroni +7 more
wiley +1 more source
Efficacy of Drug-Eluting Stents for Treating In-Stent Restenosis of Drug-Eluting Stents (from the Korean DES ISR Multicenter Registry Study [KISS]) [PDF]
, 2011 Young‐Guk Ko +12 more
openalex +1 more source
Signaling Vision: Knowing When to Quit
International Economic Review, EarlyView.ABSTRACT We study a signaling game where agents signal their type by choosing when to quit pursuing an uncertain project. High types observe news about project quality and quit when bad news arrives. Low types who do not observe any news may mimic high types by quitting continuously over a phase of time.
Junichiro Ishida, Wing Suen
wiley +1 more source
International Journal of Dermatology, EarlyView.Meta‐analysis of randomized controlled trials demonstrates that oral icotrokinra significantly improves PASI responses in patients with moderate‐to‐severe plaque psoriasis, with early clinical benefit and a placebo‐comparable safety profile, supported by trial sequential analysis confirming robust and sufficient evidence.
Alhasan Altayf +5 more
wiley +1 more source