Results 51 to 60 of about 667,813 (313)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source

Czechoslovak Support for the Founding of Israel in the Late 1940s: the Myth of Everlasting Friendship?

Czech Journal of International Relations
The war between Israel and Hamas that began in October 2023 deeply polarized public and political opinion worldwide. In contrast to many EU countries, the Czech Republic adopted a position of unwavering support for Israel, referencing their shared values
EVA TATEROVÁ
doaj   +1 more source

Statehood of Palestine and the Exercise of Jurisdiction by the International Criminal Court with Emphasis on the Decision of the Pre-Trial Chamber [PDF]

پژوهشهای حقوقی
The occupation of a large part of Palestinian lands and long history of war and killings in parts of the said land have always made the existence of a Palestinian state in international law ambiguous.
Savalan Mohamadzadeh, SEYED TAHA MOUSAVI MIRKOLAEI, keivan eghbali   +2 more
doaj   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Czech Foreign Policy towards Israel, Gaza and Palestine: An Introduction

Czech Journal of International Relations
This text introduces the special forum focusing on the Czech foreign policy towards Israel and Palestine in the wake of the Hamas’ October 7 attack and the ensuing Israeli war in Gaza.
JAKUB ZÁHORA, Jan Daniel
doaj   +1 more source

An annotated checklist of the thrips of Israel (Thysanoptera) [PDF]

, 2012
One hundred and fifty-seven species of Thysanoptera are recorded from Israel, including 32 newly recorded species. A bibliography on this thrips fauna is provided. The thrips in Israel comprise two groups: the native and the introduced species.
Kuslitzky, Wolf, zur Strassen, Richard
core  

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Freiheit zu Schweigen? Die deutsche Kommunikationswissenschaft im Nahostdiskurs

Global Media Journal: German Edition
Since the Hamas attack on Israel on October 7, 2023, and the widespread bombing and invasion of the Gaza Strip by the Israeli military, Germany’s political public sphere has been in a concern-ing state.
Christian Strippel, Kai Hafez, Carsten Reinemann, Mandy Tröger   +3 more
doaj   +1 more source

Positioning the Turkish Navy in the Eastern Mediterranean Strategic Triangle [PDF]

Codrul Cosminului
This study analyses Türkiye's naval strategy in the Eastern Mediterranean within the framework of the strategic triangle model. By applying the strategic triangle model to the multidimensional competition evident in the Eastern Mediterranean, the author ...
Meysune Yasar
doaj   +1 more source