Results 81 to 90 of about 556,138 (316)

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

The Dictyopharidae (Homoptera: Cicadina: Fulgoroidea) of Israel

, 2012
Sixteen species of Dictyopharidae (Tachorga—2 species, Nymphorgerius—1 species, Coppa—2 species, Dictyophara—9 species, and Raivuna—2 species) are recorded from Israel, and an illustrated key for their identification is provided. The general distribution
Freidberg, Amnon, Emeljanov, Alexander, Stern, Tirza   +2 more
core  

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

An observational analysis of shade-related pedestrian activity

Buildings & Cities
The impact of shade on pedestrian travel activity is examined through observation of a large sample of sidewalk users at a variety of urban sites under hot and sunny conditions.
Michelle Levenson, David Pearlmutter, Or Aleksandrowicz   +2 more
doaj   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Sentiment Analysis On Boycott Movement: NVivo Approach

Iqtishaduna: Jurnal Ilmiah Ekonomi Kita
Many countries have carried out the boycott, divestment, and sanction (BDS) movement. Research on this topic contains an interesting sentimental side and needs to be mapped to help future research. This study aims to determine the problem's evolution and
Siti Fatimah Azzahro, Indra Indra
doaj   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Rabbis in Israel, Public Relations and Advertising

Religion and Social Communication
This article discusses public relations (PR) and advertising in the work of the rabbi in Israel. The rabbi’s influence is felt within the religious population such as through the Sabbath sermon from the synagogue pulpit to congregants, but the media is ...
Yoel Cohen
doaj   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Perceptions of Jewish and Israelis in Italy: Evidence from a Survey Experiment on Political Orientation

Partecipazione e Conflitto
Following the Hamas attacks of October 7, 2023, and the subsequent outbreak of another phase of the Israel-Palestine conflict, the debate on whether criticism of Israel can mask antisemitic prejudice in Western countries has intensified.
Enea Fiore, Moreno Mancosu, Gianmaria Pessina   +2 more
doaj