Results 151 to 160 of about 1,012,175 (311)

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Public Perceptions and Career Intentions Regarding Clinical Nurse Specialist and Physician Associate Roles: A Cross-Sectional Survey. [PDF]

Int Nurs Rev
Ben Natan M, Ben Zeev Y, Bezelanski N.
europepmc   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Different Types of Traumatic Exposure Link Divergently to PTSD and CPTSD. [PDF]

Stress Health
Palgi Y, Greenblatt-Kimron L, Grossman ES, Shrira A.   +3 more
europepmc   +1 more source

FomA‐Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL‐6‐Dependent M2b Macrophage Polarization

Advanced Science, EarlyView.
Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan, Weijia Li, Wenxue Huang, Jilin Wu, Yao Yu, Yiyao Huang, Lin Yang, Ming Xie, Qishen Yang, Jun Zheng, Yuexuan Zhu, Qi Sun, Biao Li, Leqian Li, Zongwei Wang, Jie Zhao, Peng Wu, Bisheng Cheng   +17 more
wiley   +1 more source

Robust Smart Superhydrophobic Cilia

Advanced Science, EarlyView.
To date, ciliated surfaces cannot withstand mechanical damage because cilia/wires are inherently fragile. By aligning magneto‐responsive, flexible, superhydrophobic microwires on the sidewall of vertical frames, the frames act as armors to protect microwires from mechanical damage; when needed, the microwires re‐align uprightly under a magnet field to ...
Chuanqi Wei, Baixue Li, Yimeng Zhang, Oleg V. Gendelman, Youhua Jiang   +4 more
wiley   +1 more source

Awake vs. Sedated Cannulation for Extra-Corporeal Membrane Oxygenation in Patients with COVID-19 Induced Acute Respiratory Distress Syndrome. [PDF]

J Clin Med
Galante O, Bukhin A, Sagie N, Stavi D, Kasiff Y, Haviv Y, Makhoul M, Soroksky A, Zikri-Ditch M, Fink D, Ilgiyaev E.   +10 more
europepmc   +1 more source

Toward Reliable Metal Halide Perovskite FETs: From Electronic Structure and Device Physics to Stability and Performance Engineering

Advanced Electronic Materials, EarlyView.
Metal halide perovskite field‐effect transistors (PeFETs) offer great promise for flexible, low‐cost, and high‐performance due to their excellent charge carrier properties. However, challenges like ion migration, hysteresis, and instability limit their performance.
Georgios Chatzigiannakis, Anastasia Soultati, Leonidas C. Palilis, Ermioni Polydorou, Konstantinos Davazoglou, Petros‐Panagis Filippatos, Goutham Raj Perumallapelli, Ravindra Naik Bukke, Abd. Rashid bin Mohd Yusoff, Ilhwan Ryu, Peng Gao, Alexander Chroneos, Mohammad Khaja Nazeeruddin, Maria Vasilopoulou   +13 more
wiley   +1 more source

The digital transformation of healthcare: a national cross-sectional study on usage, patterns, attitudes, and barriers across social groups in Israel. [PDF]

Front Public Health
Toren O, Madar G, Reicher S.
europepmc   +1 more source

AN UNDOCUMENTED ECONOMY OF CONTROL: Workers, smugglers and State authorities in southern Israel/Palestine

, 2012
This article focuses on informal crossings of undocumented Palestinian workers from the southern West Bank to Israel. Relying on ethnographic data, it studies the modes of organization and the ramifications of this border crossing economy throughout the ...
Parizot, Cedric
core   +1 more source