Results 161 to 170 of about 56,605 (262)

Risk factors and preliminary prediction models for trauma-induced coagulopathy and 28-day mortality in severely injured patients: a retrospective observational cohort study. [PDF]

Front Med (Lausanne)
Cui S, Dong Y, Chen Y, Jiang Z, Wang H, Chen Z, Jiang Z, Zhang Z.   +7 more
europepmc   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Older age and post-traumatic organ failure a TraumaRegister DGU^® analysis of 34,469 elderly major trauma patients. [PDF]

Eur J Trauma Emerg Surg
Bewersdorf TN, Lefering R, Stein S, Streblow J, Findeisen S, Schmidmaier G, Grossner T.   +6 more
europepmc   +1 more source

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

When Timing Matters Most: Early Relapse Outweighs Baseline Risk in Myeloma. [PDF]

Cancer Med
Shan X, Susanibar-Adaniya SP.
europepmc   +1 more source

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

Advanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto, Emily Tsang, Marie Karen Tracy Hong Lin, Luca Mannino, Kurt V. Gothelf, Anja Boisen   +5 more
wiley   +1 more source

Efficacy of pan-computed tomography scan in trauma patients presenting in the emergency department of a tertiary care center: an observational study. [PDF]

Ann Med Surg (Lond)
Regmi S, Niraula BB, Poudel P, Karki PD, Dahal S, Khakurel P, Pradhan I.   +6 more
europepmc   +1 more source

Emergent 3D Fermiology and Magnetism in an Intercalated Van der Waals System

Advanced Science, EarlyView.
An emergent three‐dimensional electronic state is uncovered in an intercalated van der Waals system. A spin‐polarized intercalant‐host hybridized band crossing the Fermi level provides an itinerant channel for interlayer exchange, highlighting how electronic dispersion governs magnetic dimensionality.
Luigi Camerano, Emanuel A. Martínez, Victor Porée, Laura Martella, Dario Mastrippolito, Debora Pierucci, Franco D'Orazio, Polina M. Sheverdyaeva, Paolo Moras, Enrico Della Valle, Tianlun Yu, Moritz Hoesch, Craig M. Polley, Thiagarajan Balasubramanian, Alessandro Nicolaou, Luca Ottaviano, Vladimir N. Strocov, Gianni Profeta, Federico Bisti   +18 more
wiley   +1 more source

ICDPICR2 calculates abbreviated injury scale scores from diagnostic codes: limitations for traumatic brain injury epidemiology. [PDF]

Inj Epidemiol
Piatt J.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source