Advanced Science, EarlyView.This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi +10 more
wiley +1 more source
Chronic Kidney Disease and Superimposed Acute Kidney Injury: Greater Impact of Acute Insults on Outcomes. [PDF]
Int J NephrolChagas MW, Dias DB, Zamoner W, Ponce D.
europepmc +1 more source
All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery
Advanced Science, EarlyView.Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi +15 more
wiley +1 more source
Changes in the diagnosis, treatment, and prognosis of multiple myeloma in southern Jiangxi Province from 2012 to 2022. [PDF]
Medicine (Baltimore)Xiao Q +6 more
europepmc +1 more source
Advanced Science, EarlyView.A self‐recoverable flexible porous sensor with diverse designability of electrodes is developed through writable vapor phase polymerization using shape memory polymers (SMPs) as the fundamental materials. The sensors enable long‐term comprehensive human motion detection.
Ying Gao +7 more
wiley +1 more source
Biomechanical analysis of iliosacral and transiliac-transsacral screw combinations for fixation of undisplaced Denis II vertical shear fractures in dysmorphic sacrum. [PDF]
PeerJZhao P +5 more
europepmc +1 more source
Advanced Science, EarlyView.Transition metal and chalcogen substituents are introduced into 2D antiferromagnet, NiPS3, and comprehensive photoluminescence and Raman spectroscopy studies are conducted to investigate how spin orbit entangled exciton and two magnon scattering evolve as functions of substituent concentration.
Cong Tai Trinh +12 more
wiley +1 more source
The influence of socioeconomic status on pre-hospital triage in the Netherlands; a multi-center cohort study. [PDF]
Eur J Trauma Emerg SurgGulickx M +5 more
europepmc +1 more source
Advanced Science, EarlyView.The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda +10 more
wiley +1 more source
Trauma outcomes in elderly patients referring to the emergency department via the rapid emergency medicine score, injury severity score, and geriatric trauma outcome score indices. [PDF]
Int J Emerg MedBozorgi F +5 more
europepmc +1 more source