Results 41 to 50 of about 839,529 (283)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The impact of parents’ education and attending vocational high school to college entrance

Jurnal Pendidikan Vokasi, 2018
Using IFLS data 2007 and 2014, this study aims to examine the impact of parents’ education and attending vocational high school to the probability of children attending tertiary education.
Wahyudi Wicaksono, Robert A. Sparrow, Peter van Bergeijk   +2 more
doaj   +1 more source

Interlayer shear strength of single crystalline graphite

, 2012
Reported values (0.2 MPa ~ 7.0 GPa) of the interlayer shear strength (ISS) of graphite are very dispersed. The main challenge to obtain a reliable value of ISS is the lack of precise experimental methods.
Liu, Jefferson Zhe, Liu, Ze, Yang, Jiarui, Yang, Yanlian, Zhang, Shoumo, Zheng, Quanshui   +5 more
core   +1 more source

Holographic metastability [PDF]

, 2010
We show how supersymmetric QCD in a slice of AdS can naturally acquire metastable vacua. The formulation closely follows that of Intriligator, Seiberg and Shih (ISS), with an "electric" sector on the UV brane and a "magnetic" sector on the IR brane ...
AE Nelson, CA Scrucca, CG Callan Jr, D Marti, E Dudas, E Witten, E Witten, F Brümmer, Felix Brümmer, H Abe, H Murayama, I Affleck, I Affleck, I Affleck, JM Maldacena, JR Ellis, KA Intriligator, KA Intriligator, L Randall, M Dine, M Dine, M Dine, MA Luty, N Arkani-Hamed, N Arkani-Hamed, N Seiberg, O Aharony, R Barbieri, R Rattazzi, S Dimopoulos, S Groot Nibbelink, S Kachru, SA Abel, SS Gubser, Steven Abel, T Gherghetta, WD Goldberger   +36 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Co-circulation of the two influenza B lineages during 13 consecutive influenza surveillance seasons in Italy, 2004–2017

BMC Infectious Diseases, 2019
Background Since 1985, two antigenically distinct lineages of influenza B viruses (Victoria-like and Yamagata-like) have circulated globally. Trivalent seasonal influenza vaccines contain two circulating influenza A strains but a single B strain and thus
Simona Puzelli, Angela Di Martino, Marzia Facchini, Concetta Fabiani, Laura Calzoletti, Giuseppina Di Mario, Annapina Palmieri, Paola Affanni, Barbara Camilloni, Maria Chironna, Pierlanfranco D’Agaro, Simone Giannecchini, Elena Pariani, Caterina Serra, Caterina Rizzo, Antonino Bella, Isabella Donatelli, Maria Rita Castrucci, the Italian Influenza Laboratory Network   +18 more
doaj   +1 more source

Observations of Ion Density and Temperature around the International Space Station During two Geomagnetic Storms [PDF]

, 2018
The International Space Station (ISS) is a low Earth orbit research facility and host to an international crew. Geomagnetic storms cause changes in the Earth’s magnetic field and affect the ion density and temperature in the ionosphere which could pose a
Wright, Alex M
core   +1 more source