Results 91 to 100 of about 126,961 (341)

MTFR2‐Mediated Fission Drives Fatty Acid and Mitochondrial Co‐Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis

Advanced Science, EarlyView.
In the tumor margin of hepatocellular carcinoma (HCC), activated hepatic stellate cells upregulate MTFR2, initiating inhibiting DRP1 degradation and mitochondrial fission. This enhances mitochondrial availability and facilitates FAs synthesis via ACC1. Additionally, fission promotes RAC1‐mediated cytoskeletal remodeling and Miro1‐mediated mitochondrial
La Zhang, Baoyong Zhou, Jun Yang, Cong Ren, Jing Luo, Zhenghang Li, Qiang Liu, Zuotian Huang, Zhongjun Wu, Ning Jiang   +9 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Urban Geopolitics and the Protection of Istanbul’s Critical Infrastructures: A Participatory Urban Security Approach

Güvenlik Stratejileri Dergisi
This study aims to identify Istanbul’s critical infrastructures and explore a participatory urban security approach to ensure their protection.
İsmail Karaman, Mehmet Cem Oğultürk
doaj   +1 more source

m6A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

Advanced Science, EarlyView.
TMCO3 as a downstream target of ALKBH5 is found, which regulates its expression in an m6A‐dependent manner, and then a new phosphorylation site on TMCO3 is identified and determines the specific mechanism of TMCO3 with AKT. Moreover, the combined treatment of targeting the TMCO3 and inhibition of AKT in mice models with HCC achieves great results ...
Xinxin Li, Mengzhen Han, He Zhu, Yonglong Pan, Chen Su, Yachong Liu, Zhibin Liao, Bixiang Zhang, Xiaoping Chen   +8 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Synthesis of Pt Carbon Aerogel Electrocatalysts with Multiscale Porosity Derived from Cellulose and Chitosan Biopolymer Aerogels via Supercritical Deposition for Hydrogen Evolution Reaction

Advanced Energy and Sustainability Research, EarlyView.
The synthesis of platinumcarbon aerogel electrocatalysts with multiscale porosity derived from biopolymer aerogels via supercritical deposition is presented. The electrocatalysts demonstrate similar overpotentials to commercial alternatives with significantly higher platinum loadings, while exhibiting superior stability due to enhanced porosity ...
Ala Alsuhile, Philip Sidney Pein, Şansim Bengisu Barım, Selmi Erim Bozbağ, Irina Smirnova, Can Erkey, Baldur Schroeter   +6 more
wiley   +1 more source

Factors associated with cardiovascular events after simultaneous liver–kidney transplant from the US Multicenter Simultaneous Liver–Kidney Transplant Consortium

Hepatology Communications, EarlyView., 2022
Abstract Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver–kidney transplant (SLKT) are unknown. This was a retrospective cohort study of adult SLKT recipients between 2002 and 2017 at six centers in six United Network ...
Jennifer Jo, Gonzalo Crespo, Dyanna Gregory, Jasmine Sinha, Jiaheng Xie, Min Zhang, John Magee, Pranab Barman, Yuval A. Patel, Aaron Schluger, Kara Walters, Scott Biggins, Natalia Filipek, Giuseppe Cullaro, Randi Wong, Jennifer C. Lai, Gabriel J. Perreault, Elizabeth C. Verna, Pratima Sharma, Lisa B. VanWagner   +19 more
wiley   +1 more source

Large Language Model‐Based Chatbots in Higher Education

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
The use of large language models (LLMs) in higher education can facilitate personalized learning experiences, advance asynchronized learning, and support instructors, students, and researchers across diverse fields. The development of regulations and guidelines that address ethical and legal issues is essential to ensure safe and responsible adaptation
Defne Yigci, Merve Eryilmaz, Ail K. Yetisen, Savas Tasoglu, Aydogan Ozcan   +4 more
wiley   +1 more source

Georgeon, F. (2017). Le mois le plus long: Ramadan à Istanbul, Paris: Cnrs Éditions, 352 s.

Türkiye Din Eğitimi Araştırmaları Dergisi, 2017
Fransız tarihçi François Georgeon’un son eseri Le mois le plus long: Ramadan à Istanbul (En Uzun Ay: İstanbul’da Ramazan), III. Selim’in tahta çıkışından, II.
Yasin Özdemir
doaj  

مكاتب الصبيان في العمارة العثمانية بمدينة استانبول في ضوء خريطة أيفردي خلال القرن (13هـ/19م) Primary Schools in Ottoman Architecture in Istanbul from the Ayverdi Map during the 13AH-19AD Centuries [PDF]

Journal of General Union of Arab Archaeologists
الملخص : تُعدُّ مكاتب الصبيان في العمارة العثمانية من عناصر الانتفاع العامة التي تؤدي وظيفة تعليمية واجتماعية يستفيد بها الأطفال، فقد كانت وظيفتها تعليم الأطفال القرآن الكريم، والقراءة، والكتابة، وكانت تقام بمدينة استانبول إما داخل الكليات المعمارية أو
Heba Hamed Abdel- Hamied Mahmoud
doaj   +1 more source