Results 81 to 90 of about 562,986 (352)

H3K36me3‐Guided m6A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang   +6 more
wiley   +1 more source

İstanbul Havalimanı'nın İstanbul trafiğine etkisi

open access: yes, 2023
İstanbul’da günlük hava yolu trafiğinde yaşanan artış ile birlikte mevcut havalimanları zamanla yetersiz kalmaya başlamıştır. Avrupa Yakasında bulunan İstanbul’un ilk havalimanı olan Atatürk Havalimanı zamanla şehrin merkezinde kalmıştır. Atatürk Havalimanı Ulaştırma Bakanlığı verilerine göre kapasiteyi karşılayamayacağı kararıyla yeni havalimanı ...
Mor, Furkan, Ilıcalı, Mustafa
openaire   +1 more source

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni   +12 more
wiley   +1 more source

Surface Rolling Active Magnetic Emulsions

open access: yesAdvanced Science, EarlyView.
This study presents synergistic combination of materials to augment the life‐like chemotactic abilities of oil droplets towards microrobotics applications. Magnetically actuated autonomous oil droplets possess on‐demand switchable locomotion modalities with augmented navigation in complex confined spaces and can perform cargo transportation.
Muhammad Turab Ali Khan   +3 more
wiley   +1 more source

Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules

open access: yesAdvanced Science, EarlyView.
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu   +17 more
wiley   +1 more source

Urban Geopolitics and the Protection of Istanbul’s Critical Infrastructures: A Participatory Urban Security Approach

open access: yesGüvenlik Stratejileri Dergisi
This study aims to identify Istanbul’s critical infrastructures and explore a participatory urban security approach to ensure their protection.
İsmail Karaman, Mehmet Cem Oğultürk
doaj   +1 more source

A SPATIAL MODEL OF CHANGE OF FDI FIRM POPULATION IN ISTANBUL [PDF]

open access: yes
Within the context of the foreign capital- orientation programme having been implemented since 1980, the regulation concerning the foreign investments in Turkey were freed and this has paved the way for important developments in terms of the entrance of ...
Lale Berkoz, Sevkiye Sence Turk
core  

Split‐Standing Molecular Engineering for Textured Silicon/Perovskite Tandems

open access: yesAdvanced Science, EarlyView.
An indolocarbazole‐based HSL material (DPAICz) with a split‐standing molecular configuration is reported specifically designed for textured silicon substrates. Due to its strong anchoring stability and excellent hole extraction efficiency, monolithic textured silicon/perovskite tandem solar cells employing DPAICz as the HSL achieved a remarkable power ...
Xiaonan Wang   +11 more
wiley   +1 more source

The growth and development of metropolitan planning strategies in Istanbul [PDF]

open access: yes
Beside it?s historical, cultural and natural values in the international level, Istanbul is a world wide city which leads to national and regional development from socio-economic point of view. However, there are some obstacles to become an international
Salim Kucuk, Sebnem Yuzer
core  

Bacterial Minicell‐Based Biohybrid Sub‐micron Swimmers for Targeted Cargo Delivery

open access: yesAdvanced Science, EarlyView.
Bacterial minicells, vesicles derived from engineered E. coli, offer promising sub‐micron scale biohybrid swimmers for targeted cargo delivery. Purified with over 99% efficiency while retaining motility, they are functionalized with MNPs for controlled movement.
Saadet Fatma Baltaci   +4 more
wiley   +1 more source

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