Results 51 to 60 of about 889,439 (347)

Smart Asset Management for Electric Utilities: Big Data and Future

, 2018
This paper discusses about future challenges in terms of big data and new technologies. Utilities have been collecting data in large amounts but they are hardly utilized because they are huge in amount and also there is uncertainty associated with it ...
A Koronis, C Zhou, P Tamilselvan, SR Khuntia, SR Khuntia, V Khatri, X Peng   +6 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

An IT Asset Governance Model Design Using COBIT 2019 And ITIL V4 Framework at BKU Itenas [PDF]

E3S Web of Conferences
Information technology is considered a critical asset in both institutions and large-scale companies. Assets within an institution/company support operational activities and business processes, making them closely related to IT governance, which directly
Pratama Rayisa Yudha, Umaroh Sofia
doaj   +1 more source

Effective Asset Operation Efficiency Assessment of Power Grid Enterprises in Context of New Power System

Zhongguo dianli, 2023
The accelerated construction of new power system brings challenges to the asset management of power grid enterprises, and the accurate evaluation of asset operation efficiency is the first condition to improve the asset management level of power grid ...
Yingjin YE, Ling LIN, Di RUAN, Shiming ZHANG, Hongyang LIN   +4 more
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Asset risk assessment and management of large-scale electricity enterprises under the concept of financial sharing

Frontiers in Energy Research
The power grid is an important industry that is crucial to national security and economic development, and its importance in society continues to grow. As an emerging concept, financial sharing enables internal resource sharing and optimization, thereby ...
Bai Minyue, Yuan XiuE
doaj   +1 more source

IMPLEMENTATION OF ASSET MANAGEMENT IN ROAD ADMINISTRATION OF SLOVAK REPUBLIC [PDF]

Acta Logistica, 2014
The article presents basic principles and solutions for the application of Asset Management as part of road administration in Slovakia. It deals with application of Assets management methods and best practices of global trends in road maintenance ...
Ľubomír Pepucha, Ľuboš Remek, Juraj Šrámek, Peter Danišovič, Martin Slabej, Michal Grinč   +5 more
doaj  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source