Results 71 to 80 of about 60,443 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Predictors of College Academic Achievement for Medical Students: The Case of Gondar University, College of Medicine and Health Sciences, Ethiopia

Advances in Medical Education and Practice, 2023
Asselef T Bekele,1 Solomon W Beza,2 Shewatatek Gedamu,3,4 Markus Berndt5 1Health Workforce Improvement Program, Jhpiego, an Affiliation of Johns Hopkins University, Addis Ababa, Ethiopia; 2Human Resources for Health Directorate, Ministry of Health, Addis
Bekele AT, Beza SW, Gedamu S, Berndt M
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Strategies and motivations of high school students in career choice

Хабаршы. Психология және социология сериясы
Career choice refers to the process of self-determination among high school students regarding their future professional direction. The issue of professional self-identification and career choice among high school students remains relevant, as effective
А. Сарсенова, М. Садырова, А. Мальцева   +2 more
doaj   +1 more source

Career Choices Among Medical Students and Factors Influencing Their Choices

Global Journal of Health Science, 2019
BACKGROUND: Physicians’ specialty choices have a direct impact on medical workforce. As medical students progress through medical school, it is observed that their interests in specialties change due to one reason or another. The aim of this study is to firstly identify factors that influence medical students’ career choices using a
Nabila Aisha Mann-Isah, Nuzla Ameen, Ghufran Jassim   +2 more
openaire   +2 more sources

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

PROFESSIONAL SELF-DETERMINATION OF MOSCOW YOUTH: SOCIOLOGICAL ANALYSIS

Вестник университета, 2016
The article considers the problem of primary professional self-determination of youth. Also it presents the results of a sociological survey aimed at investigating factors influencing professional self-determination among Moscow senior and high school ...
E. Tikhonova, E. Dianina
doaj  

How Environment, Cognition, and Behavior Shape Doctoral Students’ Academic Career Intentions: Insights from a Comprehensive Study

Behavioral Sciences
Although career choice is a kind of individual behavior, as the gatekeeper of the discipline, doctoral students’ academic career intention reflects the attractiveness of the academic labor market and determines the sustainable development of academic ...
Wanhe Li, Xiaohan Jiang
doaj   +1 more source