Results 231 to 240 of about 2,389,131 (303)

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

A Survey on the Computing Continuum and Meta-Operating Systems: Perspectives, Architectures, Outcomes, and Open Challenges. [PDF]

Sensors (Basel)
Gkonis PK, Giannopoulos A, Nomikos N, Sarakis L, Nikolakakis V, Patsourakis G, Trakadas P.   +6 more
europepmc   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

How hospital accreditation requirements bridge enablers for AI readiness: interpretative analysis of intersections in framework standards. [PDF]

Front Digit Health
Bellei EA, Debon R, Costa E, De Marchi ACB.   +3 more
europepmc   +1 more source

Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing

Advanced Science, EarlyView.
This study develops a PLGA@LA‐BMP4‐PG bilayer scaffold to address scar formation and appendage loss in skin repair. The piezoelectric PLA layer enhances cell migration via electric fields, while GelMA delivers LA promoting Tregs polarization and BMP4 inhibiting FBs differentiation.
Yiwen Yang, Mingjie Kuang, Jiacheng Shi, Ruiyan Li, Yuhan Zhang, Xinting Liu, Runtan Li, Yong Kang, Bin Yao, Shuquan Zhang, Xiaoyuan Ji   +10 more
wiley   +1 more source

Empowering chronic disease management with smart healthcare in China: a policy effectiveness evaluation by PMC index model. [PDF]

Front Public Health
Yang H, Wang X, Zhang T, Zhao S, Cai R, Wang D.   +5 more
europepmc   +1 more source

A scalable and secure federated learning authentication scheme for IoT. [PDF]

Sci Rep
Chithaluru P, Jyothi BV, Alharithi FS, Ksiazek W, Ramchander M, Singh A, Rachavaram RK.   +6 more
europepmc   +1 more source

SecMLOps: A comprehensive framework for integrating security throughout the machine learning operations lifecycle. [PDF]

Empir Softw Eng
Zhang X, Zhao P, Jaskolka J, Li H, Lu R.
europepmc   +1 more source

Blockchain-enabled identity management for IoT: a multi-layered defense against adversarial AI. [PDF]

Sci Rep
Usama M, Aziz A, Alasbali N, Alturki N, Hanif M, Rehman MU.   +5 more
europepmc   +1 more source