ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
An Out‐of‐Place Etiology: Recognizing FMR1 Premutation in the Memory Clinic
ABSTRACT The FMR1 gene premutation (55–200 CGG repeats) is usually associated with a wide range of symptoms and phenotypes within the Fragile X‐tremor/ataxia syndrome (FXTAS), but may also manifest as predominant or isolated cognitive decline. We describe three male patients referred for progressive cognitive impairment and behavioral changes. Standard
Guido Greco +7 more
wiley +1 more source
Las fuentes canónicas de Pedro Damian y el movimiento de reforma antegregoriana en Italia [PDF]
Godehardo Wahner
openalex +1 more source
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source
Rischi ed effetti patologici nell'attuazione degli strumenti di democrazia partecipativa. Osservazioni per costruire un percorso di qualità della democrazia [PDF]
Il presente lavoro ha come scopo l’individuazione e la concettualizzazione dei rischi e degli effetti patologici che possono avere luogo all’interno dei processi di attuazione degli strumenti di democrazia partecipativa.
Nicola Pettinari
doaj
Fabrizio Cigni, La materia narrativa arturiana tra Francia e Toscana: un riesame per tipologie di manoscritti, in Studi sulla Letteratura Cavalleresca in Francia e in Italia (secoli [PDF]
Maria Colombo Timelli
openalex +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Premio di maggioranza ed eguaglianza del voto. Osservazioni a margine della sentenza Corte cost. 1/2014 [PDF]
Il contributo ricostruisce il principio di eguaglianza del voto, sancito dall’art. 48 Cost., alla luce sia della più rilevante dottrina giuridica che della giurisprudenza costituzionale. In particolare, viene ripercorsa l’interpretazione offerta sul tema
Valeria Piergigli
doaj
Objective To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis–associated uveitis (JIA‐U) or chronic anterior antinuclear antibody–positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease‐modifying antirheumatic drugs (bDMARDs).
Athimalaipet V. Ramanan +7 more
wiley +1 more source
Objective This systematic review aimed to assess the diagnostic accuracy of algorithms used to identify rheumatoid arthritis and juvenile idiopathic arthritis in electronic health records. Methods We searched Medline, Embase, and Cochrane Central Register for Controlled Trials databases and included studies that validated case definitions against a ...
Constanza Saka‐Herrán +10 more
wiley +1 more source

