Results 141 to 150 of about 886,817 (253)

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Rare disease clinical trials in Italy (2022-May 2026): current trends, future challenges, and the evolving role as reporting member state. [PDF]

Front Pharmacol
De Paola E, Galliccia F, Maione R, Verrelli NM, Dri DA.   +4 more
europepmc   +1 more source

Intensified Manufactured Non‐Belonging: Working Holiday Makers in Australia During the COVID‐19 Pandemic

Australian Journal of Social Issues, EarlyView.
ABSTRACT Nations manufacture non‐belonging of temporary migrants through policy frameworks that produce exclusion. This precarity maximises the economic benefit of temporary migrant labour by minimising their political, social and legal rights. In this paper, we examine how non‐belonging targeting Working Holiday Makers (WHMs) is manufactured in ...
Donna James, Alanna Kamp
wiley   +1 more source

Self‐Assembled Pt(II) Complexes Boost Up Stem Cell Proliferation and Accelerate Metamorphosis in Living Organisms

Angewandte Chemie, EarlyView.
Pt1, an organometallic platinum‐based complex, act as a modulator of redox homeostasis in cnidarians, regulating cellular functions and life‐cycle dynamics. In Nematostella vectensis, it mitigates oxidative stress, strengthens detox systems and accelerates development.
Giuseppina Tommasini, Tania Pecoraro, Anna Lewinska, Maciej Wnuk, Olga Kolodziej, Daniela Intartaglia, Simona Morgera, Alessandro Aliprandi, Giulia Veronesi, Giorgio Facchetti, Isabella Rimoldi, Angela Tino, Claudia Tortiglione, Luisa De Cola   +13 more
wiley   +2 more sources

El intento de implantar una «autonomía diferenciada» en Italia: Un mal comienzo con un incierto fin

Revista Vasca de Administración Pública
On June 19, 2024, the Italian Chamber of Deputies approved Law No. 86, on provisions for the implementation of differentiated autonomy for the ordinary statute regions, in accordance with Article 116, paragraph 3 of the Constitution.
Miguel Ángel Cabellos Espiérrez
doaj   +1 more source

From Recognition to Action: Bridging Science and Policy through the Italian Obesity Law - A Model for Europe. [PDF]

Obes Facts
Colleluori G, Romano E, Serra F, Zani I, Manco M, Buscemi S, Sbraccia P, Busetto L.   +7 more
europepmc   +1 more source

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

Animal welfare in the European agri-food market: law, policy and veterinary roles. [PDF]

Ital J Food Saf
Celentano FE, Dimuccio MM, Conforti V, De Marzo P, Losito M, Dambrosio A, Bozzo G.   +6 more
europepmc   +1 more source

Hon. Simone Billi Member of Parliament Italian Republic

, 2019
Visit by Hon.
Ordan, Julien Marius
core  

Adenosine monophosphate–activated protein kinase activation is associated with suppression of NLRP3 inflammasome–mediated neuroinflammation in a weight‐drop model of traumatic brain injury in Sprague–Dawley rats

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the study's schematic model. Adenosine monophosphate–activated protein kinase (AMPK) activators exhibited neuroprotection in the weight‐drop model of traumatic brain injury by improving cognition and regulating oxidative stress, microglial activation, and nucleotide‐binding oligomerization domain, leucine‐rich repeat,
Triveni Kodi, Paka Sravan Kumar, Krishnadas Nandakumar, Anoop Kishore   +3 more
wiley   +1 more source