Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, EarlyView.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source
From Columbus to Cooperation - Trade and Shipping Policies from 1492 to 1992 [PDF]
, 1989 This Article summarizes the history of international trade agreements from the time of Columbus to the ...
Sweeney, Joseph C.
core +2 more sources
L'unificazione nazionale e l'eccezionalità italiana
Storicamente, 2011 Scipione Guarracino
doaj +1 more source
The Future of EMU: What Does the History of Monetary Unions Tell Us? [PDF]
The creation of EMU and the ECB has triggered a discussion of the future of EMU. Independent observers have pointed to a number of shortcomings or hazard areas' in the construction of EMU, such as the absence of a central lender of last resort function ...
Lars Jonung, Michael D. Bordo
core
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
La storia del Risorgimento italiano in rete. Siti web e fonti online
Storicamente, 2011 Maria Pia Casalena, Clizia Magoni
doaj +1 more source
Convergence among Italian Regions, 1861-2011 [PDF]
In 150 years, the trends in regional disparities in economic development within Italy have differed depending on whether they are gauged by longitude or by latitude.
Gianfranco Viesti +2 more
core
Qua Re qui possum non esse popularis: The representation of Populares in the Late Roman Republic. [PDF]
, 2015 The terms popularis and optimate have been employed in both ancient and modern literature to interpret late Roman Republican politics. The purpose of this work is to express the diversity and change of the popularis label from 133 to 88 B.C.
N/A, Nash, Michael A.
core
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Scuola, igiene e nation building: maestri e medici nell’Italia liberale
Diacronie. Studi di Storia Contemporanea, 2019 This work is focused on the relationship between the process of Nation-Building and bourgeois civilization after the Italian unification and the teaching of hygienic knowledge in the schools.
Manuele Gianfrancesco
doaj