Results 111 to 120 of about 790,581 (296)

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

open access: yesAdvanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie   +15 more
wiley   +1 more source

Constant-depth circuits for Boolean functions and quantum memory devices using multi-qubit gates [PDF]

open access: yesQuantum
We explore the power of the unbounded Fan-Out gate and the Global Tunable gates generated by Ising-type Hamiltonians in constructing constant-depth quantum circuits, with particular attention to quantum memory devices.
Jonathan Allcock   +4 more
doaj   +1 more source

Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range

open access: yesAdvanced Science, EarlyView.
ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen   +8 more
wiley   +1 more source

BrainFusion: a Low‐Code, Reproducible, and Deployable Software Framework for Multimodal Brain‒Computer Interface and Brain‒Body Interaction Research

open access: yesAdvanced Science, EarlyView.
BrainFusion is a low‐code software framework for multimodal brain–computer interface (BCI)​​ and brain–body interaction research. It supports ​electroencephalography (EEG)​, functional near‐infrared spectroscopy (fNIRS), electromyography (EMG)​, and electrocardiography (ECG)​​ integration with standardized preprocessing, feature fusion, and model ...
Wenhao Li   +10 more
wiley   +1 more source

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

open access: yesAdvanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen   +16 more
wiley   +1 more source

The Law of the Iterated Logarithm for Lp-Norms of Kernel Estimators of Cumulative Distribution Functions

open access: yesMathematics
In this paper, we consider the strong convergence of Lp-norms (p≥1) of a kernel estimator of a cumulative distribution function (CDF). Under some mild conditions, the law of the iterated logarithm (LIL) for the Lp-norms of empirical processes is extended
Fuxia Cheng
doaj   +1 more source

Abiotic Factors and Plant Communities Shape the Distribution of Soil Pathogenic Oomycetes in Chinese Grasslands

open access: yesAdvanced Science, EarlyView.
The continental‐scale study reveals that soil phosphorus strongly predicts the richness of soil pathogenic oomycetes in Chinese grasslands, while precipitation and plant species richness drive their absolute abundance; modeling predicts ≈42% of grassland areas may face elevated oomycete disease risk under future climate scenarios, especially in typical
Junsheng Ke   +10 more
wiley   +1 more source

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