Results 31 to 40 of about 236,189 (238)
Adaptive development and maintenance of user-centric software systems [PDF]
, 2004 A software system cannot be developed without considering the various facets of its environment. Stakeholders – including the users that play a central role – have their needs, expectations, and perceptions of a system.
Alspaugh +24 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Prototyping the Power Hall: a decision-making process
Science Museum Group JournalInteractive gallery interpretation is seen as a valuable tool for engaging families with the subject of science and engineering. It can offer many opportunities for creating active learning experiences and can help stimulate visitor interest and ...
Christina Buckingham
doaj +1 more source
Complex Systems Informatics and Modeling Quarterly, 2016 In a user-centered development process, artifacts evolve in iterative cycles until they meet users’ requirements and then become the final product. Every cycle gives the opportunity to revise the design and to introduce new requirements which might ...
Thiago Rocha Silva +2 more
doaj +1 more source
Practical Strategies for Integrating a Conversation Analyst in an Iterative Design Process
, 2002 We present a case study of an iterative design process that includes a conversation analyst. We discuss potential benefits of conversation analysis for design, and we describe our strategies for integrating the conversation analyst in the design process.
Aoki, Paul M. +3 more
core +2 more sources
Shared Arrangements: practical inter-query sharing for streaming dataflows
, 2020 Current systems for data-parallel, incremental processing and view maintenance over high-rate streams isolate the execution of independent queries. This creates unwanted redundancy and overhead in the presence of concurrent incrementally maintained ...
Lattuada, Andrea +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Advances in Human-Computer Interaction, 2008 Young children with multiple disabilities (e.g., both cognitive and motor disabilities) are confronted with severe limitations in language development from birth and later on.
Bart Hengeveld +6 more
doaj +1 more source
An evaluation of scaffolding for virtual interactive tutorials [PDF]
, 2002 Scaffolding refers to a temporary support framework used during construction. Applied to teaching and learning it describes measures to support a learner to become confident and self-reliant in a subject. In a Web environment scaffolding features need to
Pahl, Claus
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source