Results 81 to 90 of about 132,832 (312)

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Reduced Complexity In-Phase/Quadrature-Phase M-QAM Turbo Equalization Using Iterative Channel Estimation [PDF]

, 2003
A reduced complexity trellis-based turbo equalizer known as the in-phase (I)/quadrature-phase (Q) turbo equalizer (TEQ-IQ) invoking iterative channel impulse response (CIR) estimation is proposed. The underlying principle of TEQ-IQ is based on equalizing
Yeap, B.L., Wong, C.H., Hanzo, L.
core  

Iterative detected sphere packing modulated OFDM: An EXIT chart perspective [PDF]

, 2008
A novel iteratively detected Sphere Packing (SP) modulation aided Orthogonal Frequency Division Multiplexing (OFDM) scheme is proposed, which we refer to as the SP- OFDM arrangement.
Alamri, Osamah, M. El-Hajjar, S. Chen, Chen, Sheng, Xu, Lei, El Hajjar, Mohammed, O. Alamri, L. Hanzo, Hanzo, Lajos, L. Xu   +9 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Approximate Maximum Margin Algorithms with Rules Controlled by the Number of Mistakes [PDF]

, 2006
We present a family of Perceptron-like algorithms with margin in which both the “effective” learning rate, defined as the ratio of the learning rate to the length of the weight vector, and the misclassification condition are independent of the length of ...
Shawe-Taylor, John, John Shawe-taylor, Tsampouka, Petroula, Petroula Tsampouka   +3 more
core   +1 more source

Artificial Intelligence–Based Online Symptom Assessment Tools for Systemic Lupus Erythematosus Diagnosis: Patient Perspectives

Arthritis Care &Research, EarlyView.
Objective The objective of this article is to identify perceptions of patients with systemic lupus erythematosus (SLE) regarding artificial intelligence (AI)–based online symptom assessment tools, and the potential of these tools to address diagnostic barriers.
Olivia A. Stein, Jennifer L. F. Lee, Evelyne Vinet, Arielle Mendel, Christian A. Pineau, Fares Kalache, Louis‐Pierre Grenier, Sasha Bernatsky   +7 more
wiley   +1 more source

Hybrid Iterative Multiuser Detection for Channel Coded Space Division Multiple Access OFDM Systems [PDF]

, 2006
Space division multiple access (SDMA) aided orthogonal frequency division multiplexing (OFDM) systems assisted by efficient multiuser detection (MUD) techniques have recently attracted intensive research interests.
Jiang, M., M. Jiang, Ng, S. X., S.X. Ng, L. Hanzo, Hanzo, L.   +5 more
core   +1 more source

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, Accepted Article.
Objective VEXAS syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures. A VEXAS‐specific disease activity index (DAI) is an essential tool for reliably capturing changes in disease ...
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source

Goal Orientated stroke rehabilitation utilising electrical stimulation, iterative learning and Microsoft Kinect [PDF]

, 2013
An upper-limb stroke rehabilitation system is developed that assists patients in performing real world functionally relevant reaching tasks. The system provides de-weighting of the arm via a simple spring support whilst functional electrical stimulation ...
Timothy Exell, Hallewell, Emma, Eric Rogers, Katie Meadmore, Hughes, Ann-Marie, Christopher Freeman, Kutlu, Mustafa, Ann-Marie Hughes, Mustafa Kutlu, Freeman, Christopher, Emma Hallewell, Meadmore, Katie, Exell, Timothy, Jane Burridge, Burridge, Jane H., Rogers, Eric   +15 more
core   +1 more source