Advanced Science, EarlyView.We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du +11 more
wiley +1 more source
An improved Wexler algorithm for electrical impedance tomography using finite element method and gradient based overrelaxation. [PDF]
Sci RepJurgielewicz M, Walczyk CJ.
europepmc +1 more source
AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint
Advanced Science, EarlyView.AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz +4 more
wiley +1 more source
AI-Augmented Iterative Screening of Libraries Against RNA Targets (AISLAR) Boosts Discovery of SAR-Tractable RNA Binders and Rational Analog Design. [PDF]
Small SciHattori H +6 more
europepmc +1 more source
stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics
Advanced Science, EarlyView.stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang +3 more
wiley +1 more source
Deep-learning based image reconstruction enables reduced dose CT pulmonary angiography with non-inferior image quality. [PDF]
Sci RepSender S +9 more
europepmc +1 more source
Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design
Advanced Science, EarlyView.A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram +4 more
wiley +1 more source
Smart Sensor Network Architecture with Machine Learning-Based Predictive Monitoring for High-Complexity Computed Tomography Systems. [PDF]
Sensors (Basel)Pajaziti A, Statovci B.
europepmc +1 more source
Advanced Science, EarlyView.Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg +18 more
wiley +1 more source
Evaluation of optimal ClearInfinity artificial intelligence deep learning reconstruction algorithm weights with a 70-kVp tube voltage combined with "dual-low" abdominal computed tomography angiography. [PDF]
Quant Imaging Med SurgXiang J +6 more
europepmc +1 more source