TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Non-Iterative Reconstruction and Selection Network-Assisted Channel Estimation for mmWave MIMO Communications. [PDF]
Yang J, Guo Y, Guo X, Wang P.
europepmc +1 more source
ABSTRACT The multifunctional integration of chips with high flexibility and scalable manufacturing is crucial for enhancing chip performance, reducing chip size, and simplifying chip design. However, balancing volume, cost, flexibility, and functionality using traditional heterogeneous integration methods is challenging.
Lang Chen +7 more
wiley +1 more source
Segmentation of visceral and subcutaneous adipose tissue in abdominal CT-datasets with and without contrast medium: Influence of iterative reconstruction on 2D- and 3D-segmentation. [PDF]
Gohmann RF +7 more
europepmc +1 more source
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh +8 more
wiley +1 more source
Enhancing Image Quality in Dental-Maxillofacial CBCT: The Impact of Iterative Reconstruction and AI on Noise Reduction-A Systematic Review. [PDF]
Wajer R +5 more
europepmc +1 more source
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari +3 more
wiley +1 more source
Comparison of deep learning reconstruction and iterative reconstruction algorithms for virtual monoenergetic image quality in overweight and obese patients with triple-low scan protocol dual-energy carotid computed tomography angiography. [PDF]
Xu W +13 more
europepmc +1 more source
Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing +10 more
wiley +1 more source

