Results 11 to 20 of about 165 (98)

Living with the Unknown: Intolerance of Uncertainty in Parkinson's Disease. [PDF]

Mov Disord Clin Pract
Abstract Background Parkinson's disease (PD) is marked by pervasive uncertainty due to fluctuating motor and non‐motor symptoms, variable treatment response, and an unpredictable clinical course. Intolerance of uncertainty (IU), a tendency to perceive ambiguity as threatening and respond with worry, avoidance, or decisional paralysis, may be ...
McDaniels B, Pontone GM, Pushparatnam K, Subramanian I.   +3 more
europepmc   +2 more sources

Reshaping study design for faster extrapolation-based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN-NASPGHAN position paper. [PDF]

J Pediatr Gastroenterol Nutr
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Turner D, Assa A, Malham M, Bar-Asher SY, Rayan C, Hyams JS, Uhlig HH, Pasternak B, Wilson DC, Michel HK, de Ridder L, Zuckerman E, Aloi M, Szitanyi P, Dubinsky MC, Griffiths AM, Saldana R, Martín-de-Carpi J, Wine E, Russell RK, Adler J, Picoraro J.   +21 more
europepmc   +2 more sources

Disease Monitoring in Inflammatory Bowel Disease Daily Clinical Practice and Impact on Treatment Decision Making: Real World Evidence From the Inflammatory Bowel Disease-PODCAST Study. [PDF]

United European Gastroenterol J
ABSTRACT Background Crohn's disease (CD) and ulcerative colitis (UC) are progressive inflammatory bowel diseases that often result in bowel damage, imposing a significant burden on patients with insufficient disease control due to the limited efficacy of current treatments or complex disease management.
Dignass A, Magro F, D'Amico F, Bamias G, Caprioli FA, Franchimont D, Hart A, Koch R, Koutroubakis I, Siffledeen J, Toruner M, Leitner C, Heatta-Speicher T, Michelena N, Tornatore V, Gemignani L, Lapthorn J, Kauffman L, Gomollón F, IBD‐PODCAST Investigators.   +19 more
europepmc   +2 more sources

Management of paediatric ulcerative colitis, part 1: Ambulatory care-An updated evidence-based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation. [PDF]

J Pediatr Gastroenterol Nutr
Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Wine E, Aloi M, Van Biervliet S, Bronsky J, di Carpi JM, Gasparetto M, Gianolio L, Gordon H, Hojsak I, Hudson AS, Hussey S, van Limbergen J, Miele E, Norsa L, Olén O, Pellino G, van Rheenen P, de Ridder L, Russell RK, Shouval DS, Trindade E, Turner D, Wilson DC, Yerushalmy Feler A, Assa A.   +24 more
europepmc   +2 more sources

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

The Milan Ultrasound Criteria (MUC) in Pediatric Ulcerative Colitis: A Pilot Study of the Correlation With Clinical, Endoscopic and Ultrasound Activity Scores

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Background Non‐invasive monitoring tools are needed in pediatric ulcerative colitis (UC) to reduce reliance on invasive procedures. The Milan ultrasound criteria (MUC), validated in adults, has not been evaluated in children. Methods In this exploratory pilot study, 16 pediatric UC patients (< 18 years) from two Colombian centers underwent ...
Viviana Parra Izquierdo, Kenneth Ernest‐Suarez, Marjorie Argollo, Juan Sebastián Frías‐Ordoñez, Ginary Orduz, Melquicedec Vargas, Samuel Cubillos, Elisabeth Eggermont, Bram Verstockt   +8 more
wiley   +1 more source

Rational Monitoring of Patients With Inflammatory Bowel Disease in Remission: Results From the Danish DK‐MONITOR Delphi Consensus Study

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Background Monitoring strategies for patients with inflammatory bowel disease (IBD) in remission vary widely in clinical practice, reflecting limited evidence and a lack of consensus. With increasing numbers of patients living long term with IBD, there is a need for rational, clinically meaningful approaches to remission‐phase monitoring ...
Johan Burisch, Jakob B. Seidelin, Marianne Kajbæk Vester‐Andersen, Signe Wildt, Klaus Theede, Else Kjær Mikkelsen, Anders Lødrup, Mette Esbjørn, Pernille Larsen, Dorte Vind Andersen, Charlotte Riddersholm, Ulrich Martin Bick, Christiane Bro Simonsen, Lone Trier Kronkjær, Rikke Edelbo, Anders Dige, Jørgen Agnholt, Anne‐Mette Haase, Lars Koch Hansen, Anne Louise Brix Nørgaard, Osama Karim Abed, Heidi Ivarsen, Stine Hald, Charlotte Teglgaard, Christina Rasmussen, Eva Fjordside, Ebbe Langholz, Pia Berg, Torben Nathan, Rune Wilkens, Julie Gaardbo, Vladimir Gancho, Christina Juul de Blanck, Tina Weien Kristensen, Julie Rasmussen, Signe Wiese, Magid Al‐Khalaf, Atef Kinani, Charlotte Sørensen, Anja Poulsen, Torben Knudsen, Lone Larsen, Jens Kjeldsen   +42 more
wiley   +1 more source

Beyond seizures: A multidimensional approach to non‐seizure issues in Lennox–Gastaut syndrome. Insights from Italian experts

Epilepsia Open, Volume 11, Issue 4, Page 1075-1094, August 2026.
Abstract Non‐seizure issues (NSIs), including cognition, behavior/psychiatric symptoms, adaptive and social functioning, sleep, autonomic, and motor impairments, often shape day‐to‐day outcomes in Lennox–Gastaut syndrome (LGS) more than seizures, yet clinicians lack LGS‐specific, feasible assessment pathways.
Giancarlo Di Gennaro, Domenica Immacolata Battaglia, Paolo Bonanni, Gian Marco Duma, Antonietta Coppola, Edoardo Ferlazzo, Dario Pruna, Carlo Di Bonaventura   +7 more
wiley   +1 more source

Sustained Treatment Success With Ustekinumab in Symptomatic Stricturing Crohn's Disease: A Retrospective Single‐Arm Observational Cohort Study

MedComm, Volume 7, Issue 7, July 2026.
Data on ustekinumab (UST) for symptomatic stricturing Crohn's disease remain scarce in China. This cohort study screened 73 patients from June 2022 to April 2024, of whom 54 were eligible included, with 81.5% achieving 52‐week treatment success. Most attained sustained clinical remission alongside improved inflammation and strictures. Nonsmoking status
Jingwen Liu, Wen Hu, Shuyan Li, Shurong Hu, Deming Jiang, Yan Chen   +5 more
wiley   +1 more source

Intestinal Ultrasound Adds Diagnostic Value and Safety to a Dietitian‐Led Clinic for Disorders of Gut–Brain Interaction

JGH Open, Volume 10, Issue 5, May 2026.
ABSTRACT Background Disorders of gut–brain interaction (DGBI) affect approximately 40% of the global population. Multidisciplinary models incorporating dietetic management are increasingly used, yet objective assessment tools remain limited. This study evaluated the clinical utility of intestinal ultrasound (IUS) within a dietitian‐led DGBI clinic ...
R. M. Mathias, S. L. Plush, L. E. Edwards, D. Bogatic, L. Bibb, T. M. Goodsall, A. S. Day, R. V. Bryant   +7 more
wiley   +1 more source