Results 11 to 20 of about 2,280 (147)

Reshaping study design for faster extrapolation-based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN-NASPGHAN position paper. [PDF]

J Pediatr Gastroenterol Nutr
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Turner D, Assa A, Malham M, Bar-Asher SY, Rayan C, Hyams JS, Uhlig HH, Pasternak B, Wilson DC, Michel HK, de Ridder L, Zuckerman E, Aloi M, Szitanyi P, Dubinsky MC, Griffiths AM, Saldana R, Martín-de-Carpi J, Wine E, Russell RK, Adler J, Picoraro J.   +21 more
europepmc   +2 more sources

Disease Monitoring in Inflammatory Bowel Disease Daily Clinical Practice and Impact on Treatment Decision Making: Real World Evidence From the Inflammatory Bowel Disease-PODCAST Study. [PDF]

United European Gastroenterol J
ABSTRACT Background Crohn's disease (CD) and ulcerative colitis (UC) are progressive inflammatory bowel diseases that often result in bowel damage, imposing a significant burden on patients with insufficient disease control due to the limited efficacy of current treatments or complex disease management.
Dignass A, Magro F, D'Amico F, Bamias G, Caprioli FA, Franchimont D, Hart A, Koch R, Koutroubakis I, Siffledeen J, Toruner M, Leitner C, Heatta-Speicher T, Michelena N, Tornatore V, Gemignani L, Lapthorn J, Kauffman L, Gomollón F, IBD‐PODCAST Investigators.   +19 more
europepmc   +2 more sources

Management of paediatric ulcerative colitis, part 1: Ambulatory care-An updated evidence-based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation. [PDF]

J Pediatr Gastroenterol Nutr
Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Wine E, Aloi M, Van Biervliet S, Bronsky J, di Carpi JM, Gasparetto M, Gianolio L, Gordon H, Hojsak I, Hudson AS, Hussey S, van Limbergen J, Miele E, Norsa L, Olén O, Pellino G, van Rheenen P, de Ridder L, Russell RK, Shouval DS, Trindade E, Turner D, Wilson DC, Yerushalmy Feler A, Assa A.   +24 more
europepmc   +2 more sources

UEG Week 2025 Oral Presentations [PDF]

United European Gastroenterol J
United European Gastroenterology Journal, Volume 13, Issue S8, Page S7-S188, October 2025.
europepmc   +2 more sources

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Bowel Urgency Improvement Correlates With Clinical, Biochemical, and Intestinal Ultrasound Improvements in Inflammatory Bowel Disease: A Cross Sectional Multicenter Study

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Bowel urgency (BU) is reported by over 80% of patients with ulcerative colitis (UC) and 60% of those with Crohn's disease (CD). However, the impact of advanced therapies on BU has not been consistently evaluated. Objectives To assess the effect of advanced therapies on BU improvement in patients with UC and CD.
Ferdinando D'Amico, Olga Maria Nardone, Alessandro Bruno, Mariangela Allocca, Alessandra Zilli, Federica Furfaro, Tommaso Lorenzo Parigi, Virginia Solitano, Federica Ungaro, Ilaria Faggiani, Alessia La Mantia, Giulio Calabrese, Gionata Fiorino, Vipul Jairath, Laurent Peyrin‐Biroulet, Luca Massimino, Fabiana Castiglione, Silvio Danese   +17 more
wiley   +1 more source

Advancing Clinical Trial Methodology and Reporting of Outcomes for Exclusive Enteral Nutrition and Partial Enteral Nutrition in Crohn's Disease: Challenges and Recommendations

JCC Plus, Volume 1, Issue 1, January 2026.
ABSTRACT Background Exclusive enteral nutrition (EEN) is an efficacious therapy for active Crohn's disease (CD), particularly in the paediatric setting. Aim This review critically evaluates key elements of interventional EEN trials in paediatric and adult cohorts to identify areas for improvement in trial design and reporting of outcomes, with ...
Sarah L. Melton, Jessica Fitzpatrick, Matthew K. W. Chu, Konstantinos Gkikas, Emily Monro, Jemma Matthews, Emma P. Halmos, Alice S. Day   +7 more
wiley   +1 more source

Review Article: Extending the Frontiers of Intestinal Ultrasound Knowledge, Performance and Expansion

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 1, Page 40-56, January 2026.
This umbrella review identifies sizable gaps in the evidence base for intestinal ultrasound (IUS) in inflammatory bowel disease (IBD), particularly in standardised activity indices, responsiveness definitions, and applications in special populations. Addressing these gaps through robust, multicenter studies and consensus‐driven frameworks is essential ...
Cathy Lu, Bram Verstockt, Michael W. Winter, Britt Christensen, Dan Carter, Floris de Voogd, Michael Dolinger, Thomas Goodsall, Maureen O'Brien, Ryan Rosentreter, the International Bowel Ultrasound (IBUS) Group, Mariangela Allocca, Rune Wilkens   +12 more
wiley   +1 more source

UEG Week 2025 Moderated Posters [PDF]

United European Gastroenterol J
United European Gastroenterology Journal, Volume 13, Issue S8, Page S189-S802, October 2025.
europepmc   +2 more sources

Compulsion in Roman Law [PDF]

, 2006
Doctoral Thesis [portion]An overview of metus and condictio in Roman ...
Du Plessis, Jacques
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