Results 131 to 140 of about 548,008 (322)

Targeting MGAT4A‐Mediated N‐Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion

Exploration, EarlyView.
ABSTRACT Glioblastoma (GBM) is the most aggressive type of primary brain tumor, and its invasive properties contribute significantly to incomplete surgical resection and tumor recurrence. Despite extensive clinical efforts to mitigate GBM invasion, targeted therapies against GBM stem cells (GSCs), which drive invasion, remain incompletely understood ...
Rui Niu, Meichen Liu, Qingshan Yang, Jinlong Yin   +3 more
wiley   +1 more source

Magnetorotational instability in decretion disks of critically rotating stars and the outer structure of Be and Be/X-ray disks

, 2014
Evolutionary models of fast-rotating stars show that the stellar rotational velocity may approach the critical speed. Critically rotating stars cannot spin up more, therefore they lose their excess angular momentum through an equatorial outflowing disk ...
Krticka, Jiri, Krtickova, Iva, Kurfurst, Petr   +2 more
core   +1 more source

Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyltransferases-IVa Regulation

Scientific Reports, 2015
Glycosylation alterations of cell surface proteins are often observed during the progression of malignancies. The specific cell surface N-glycans were profiled in hepatocellular carcinoma (HCC) with clinical tissues (88 tumor and adjacent normal tissues)
Huan Nie, Xia Liu, Yubao Zhang, Tingting Li, Chao Zhan, W. Huo, Anshun He, Yuanfei Yao, Yueying Jin, Youpeng Qu, Xue-Long Sun, Y. Li   +11 more
semanticscholar   +1 more source

Geriatric Nutritional Risk Index Predicts Treatment Intolerance and Survival in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Malnutrition is associated with worse outcomes in head and neck cancer (HNC). The geriatric nutritional risk index (GNRI) may predict postoperative morbidity and survival, but its role remains underexplored. Methods An ambispective study of patients undergoing HNC surgery at two academic centers (2015–2024) was performed ...
Raisa Chowdhury, Alex M. Mlynarek, Keith Richardson, Nader Sadeghi, Michael P. Hier, Sabrina Wurzba, Khashayar Esfahani, Nathaniel Bouganim, Khalil Sultanem, George Shenouda, Christina Tsien, Marco A. Mascarella   +11 more
wiley   +1 more source

Resolving Conflicts of Rights: Russ Shafer-Landau and Judith Jarvis Thomson Revisited [PDF]

, 2018
This manuscript examines two accounts that discuss rights disputes. On the one hand, Russ Shafer-Landau argues for specificationism (or what is referred to here as SA), which deems rights as having innate limitations. One the other, Judith Jarvis Thomson
Soriano, Patricia Louise
core  

Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate clinical outcomes and quality of life (QOL) following hypofractionated spot‐scanning proton therapy (SSPT) for head and neck malignant mucosal melanoma (HNMM). Methods This retrospective study included 39 patients treated with SSPT (60–64 Gy[RBE] in 15–16 fractions) between 2013 and 2023.
Koichiro Nakajima, Hiromitsu Iwata, Gaku Takano, Daiki Kojima, Yukiko Hattori, Yusuke Tsuzuki, Shuou Sudo, Kensuke Hayashi, Toshiyuki Toshito, Hideo Fukano, Hiroyuki Ogino, Akio Hiwatashi   +11 more
wiley   +1 more source

Reduced the Food Effect and Enhanced the Oral Bioavailability of Ivacaftor by Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using a New Oil Phase

Drug Design, Development and Therapy, 2022
Yanfei Miao,1 Shihua Zhao,1 Jian Zuo,1 Jiqin Sun,1 Jingnan Wang2 1College of Chemistry and Chemical Engineering, Taishan University, Tai’an, People’s Republic of China; 2School of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University ...
Miao Y, Zhao S, Zuo J, Sun J, Wang J
doaj  

Pascal’s wager: tracking an intended reader in the structure of the argument [PDF]

, 2016
Pascal’s wager is the name of an argument in favor of belief in God presented by Blaise Pascal in §233 of Thoughts. Ian Hacking (1972) pointed out that Pascal’s text involves three different versions of the argument.
SVAČINOVÁ, Iva
core   +1 more source

Chloride Intracellular Channel 2 Can Function as a Malignant Factor in Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background The association of chloride intracellular channel 2 (CLIC2) with tumors has remained unclear. However, recently, CLIC2 was found to exhibit antitumor properties in some tumors. In this study, we aimed to evaluate the clinical relevance of CLIC2 expression in head and neck squamous cell carcinoma (HNSCC) to determine whether it ...
Yuki Hosokawa, Shoko Miyoshi, Yuji Hayashi, Yuki Irifune, Eriko Sato, Sohei Mitani, Mohammed Choudhury, Hajime Yano, Junya Tanaka, Naohito Hato   +9 more
wiley   +1 more source

Th17 cells favor migration and invasiveness of cervical cancer cells under hypoxia in an IGF2BP2‐dependent manner

International Journal of Cancer, EarlyView.
What's New? Hypoxic regions and inflammatory Th17 cells in the tumor environment are both associated with poor prognosis in cervical cancer. However, synergistic mechanisms between hypoxia and Th17 cells remain elusive. This study demonstrated Th17–hypoxia‐driven mechanisms underlying cervical cancer progression.
Selina Gies, Maike Pohlers, Tanja Tänzer, Emmanuel Ampofo, Matthias W. Laschke, Moritz Schäfer, Yoo‐Jin Kim, Rainer Maria Bohle, Erich‐Franz Solomayer, Konrad Wagner, Martin Empting, Alexandra K. Kiemer, Barbara Walch‐Rückheim   +12 more
wiley   +1 more source