Results 171 to 180 of about 123,445 (347)

Laypeople's Views on the Narrative Identity and Societal Treatment of Genetically Modified People

Bioethics, EarlyView.
ABSTRACT Genome editing in human embryos could raise new ethical issues by changing future people's narrative and numerical identity. Most philosophers agree that some genetic modifications would have larger effects on identity than others, but they disagree on what criteria might explain these differences and have not supported their claims ...
Derek So, Yann Joly, Robert Sladek
wiley   +1 more source

Health Professionals' Attitudes to Maternal Request for Caesarean Birth: A Scoping Review

Birth, EarlyView.
Health professionals' attitudes to maternal request for caesarean birth: a scoping review. ABSTRACT Background Caesarean birth rates are rising worldwide, and projections show that by 2030, 28.5% of women worldwide (or 38 million) will give birth by caesarean delivery.
Carol Guinan, Walsh Aisling
wiley   +1 more source

CRISPR Activation Reveals the Spliceogenicity of an Intronic NEB Variant in Fetuses With Arthrogryposis Multiplex Congenita 6

Clinical Genetics, EarlyView.
CRISPR activation of NEB in fibroblasts, followed by RNA‐sequencing, documents spliceogenic effects of a NEB intronic variant. The assay enabled variant reclassification as likely pathogenic, providing molecular diagnosis in fetuses with Arthrogryposis multiplex congenita 6.
Doriana Misceo, Thorkild Terkelsen, Sara Margrete Bøen Keim, Pål Marius Bjørnstad, Mari Elen Strand, Vivian Cecilie Orszagh, Uffe Birk Jensen, Eirik Frengen   +7 more
wiley   +1 more source

Transcription Factor TCF12‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation

Cell Proliferation, EarlyView.
Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao, Chi Zhang, Zuo‐Qi Deng, Yue‐xin Qiu, Zhao Zhang, Heng‐Yu Fan, Jing Li, Hong‐Bo Wu   +7 more
wiley   +1 more source

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

The Heterogeneous Impact of Children on Maternal Employment: Evidence From East and West Germany

Economics of Transition and Institutional Change, EarlyView.
ABSTRACT This study investigates the causal effect of fertility on female labour market outcomes in East and West Germany. We use twin births as an exogenous variation for family size. Our results suggest a negative relationship between the number of children and maternal labour market outcomes.
Johannes Köckeis, Sven Stöwhase
wiley   +1 more source

#182 : Pharmacokinetics of Ovarian Stimulation for Projected Poor Responder Patients in IVF. A Randomised Trial Comparing a Corifollitropin Alfa Agonist Flare Protocol with a Corifollitropin Alfa Antagonist Protocol

, 2023
Kaushalya Arulpragasam, Mary Elizabeth O’Neil, Prudence Sweeten, Devora Lieberman, Rachael J. Rodgers, Shannon Choi, Joan Tan, Nancy Briggs, William J. Ledger   +8 more
openalex   +1 more source

Are Dichorionic Twin Pregnancies Resulting from In Vitro Fertilization Different from Spontaneous Dichorionic Twin Pregnancies? A Retrospective Cohort Study. [PDF]

J Clin Med
Nessar AZ, Karagün Ş, Adıgüzel FI, Gül Aydın Ş, Aykut S, Kurt A, Demir SC, Sucu M, Evrüke İC.   +8 more
europepmc   +1 more source

Emotional Adjustment in Couples During and After a Failed IVF Procedure: A Systematic Review [PDF]

, 2016
Rishi Mishra, Ashwani Mohan
openalex   +1 more source

High GDF-8 in follicular fluid is associated with a low pregnancy rate in IVF patients with PCOS [PDF]

, 2020
Lanlan Fang, Sijia Wang, Yiran Li, Yiping Yu, Yuxi Li, Yang Yan, Jung‐Chien Cheng, Yingpu Sun   +7 more
openalex   +1 more source