Results 71 to 80 of about 211,282 (394)

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Various Faces of Type IIA Supergravity

, 2003
We derive a duality-symmetric action for type IIA D=10 supergravity by the Kaluza-Klein dimensional reduction of the duality-symmetric action for D=11 supergravity with the 3-form and 6-form gauge field.
Aganagic, Aganagic, Aganagic, Alexei J. Nurmagambetov, Bandos, Bandos, Bandos, Bandos, Bandos, Bandos, Bandos, Bandos, Bandos, Bekaert, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bergshoeff, Bonora, Campbell, Cariglia, Cederwall, Cederwall, Chamseddine, Chamseddine, Cremmer, Cremmer, Dall'Agata, Dall'Agata, Dall'Agata, de Azcárraga, Delduc, Dmitri P. Sorokin, Freed, Galperin, Gianni, Green, Green, Huq, Igor A. Bandos, Kalkkinen, Lavrinenko, Lechner, Lechner, Lechner, Lechner, Lechner, Lü, Naito, Nurmagambetov, Nurmagambetov, Pasti, Pasti, Pasti, Pasti, Polchinski, Romans, Sato, Schwarz, Schwarz, Sorokin, Townsend, Witten, Witten, Zheltukhin, Zheltukhin   +71 more
core   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

A pilot study and case reports on endometrial microbiota and pregnancy outcome: An analysis using 16S rRNA gene sequencing among IVF patients, and trial therapeutic intervention for dysbiotic endometrium

Reproductive Medicine and Biology, 2018
The present study aimed to analyze the pregnancy outcomes of IVF patients presenting Lactobacillus‐dominated microbiota (LDM) or non‐Lactobacillus‐dominated microbiota (NLDM) of their endometrium and to report cases who were treated for NLDM concurrently
K. Kyono, T. Hashimoto, Suguru Kikuchi, Y. Nagai, Y. Sakuraba   +4 more
semanticscholar   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Understanding the ethical concerns that have shaped European regulation of human embryonic stem cell research [PDF]

, 2012
Human embryonic stem cell research has generated much hope, but also fear and repulsion. National legislators, as well as the European Parliament, the European Patent Office and the European Court of Justice have had to make decisions relating to what is
Mertes, Heidi
core  

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Perspectives on Preimplantation Genetic Testing for Monogenic Disorders Among Japanese Patients With Hereditary Breast Cancer Undergoing Fertility Preservation: Insights From the First Japanese Survey

Reproductive Medicine and Biology
Purpose Preimplantation genetic testing for monogenic disorders (PGT‐M) offers BRCA variant carriers the option of preventing hereditary cancer transmission.
Haruhisa Konishi, Yoshiharu Nakaoka, Anmae Michiko, Sho Fujiwara, Rie Kitayama, Daisuke Kadogami, Naoharu Morimoto, Kanako Katsu, Satoko Fujioka, Tomoko Inoue, Aisaku Fukuda, Hiroki Kurahashi, Yoshiharu Morimoto   +12 more
doaj   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

#297 : The Impact of Large Perivitelline Space and Fragmented Polar Body Oocytes on the Quality of Embryos and Pregnancy Loss in IVF Program

Fertility & Reproduction, 2023
Background and Aims: Extracytoplasmic oocyte abnormalities such as Large Perivitelline Space (LPVS) and Fragmented Polar Body (FrPB) are frequently detected in human oocytes during IVF procedures.
Syifa Ghufrani Rizki, Rini Widyastuti, Deka Putri Gunarwati, Akhmad Afifudin Al-Anshori, Diar Trie Dinanty, Gita Salmah Nuraisah, Muhammad Khaerulloh, Aida Riyanti, Fachry Achmad Prodjokusumo, Budi Wiweko   +9 more
doaj   +1 more source