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Boolean analysis of the transcriptomic data to identify novel biomarkers of IVIG response
Autoimmunity Reviews, 2021 International audienceIntravenous immunoglobulin (IVIG) is used to treat several autoimmune and inflammatory diseases, but some patients are refractory to IVIG and require alternative treatments.
Srini V Kaveri +2 more
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Archivum Immunologiae et Therapiae Experimentalis, 2016
Anaphylactic reactions are a known complication in some IgA-deficient patients receiving blood or plasma transfusions. It is of particular interest that anaphylaxis has been observed in patients with common variable immunodeficiency (CVID) who are receiving intravenous gammaglobulin (IVIG), and in that, although these patients have an impaired response
Sharon Julie, Williams, Sudhir, Gupta
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Anaphylactic reactions are a known complication in some IgA-deficient patients receiving blood or plasma transfusions. It is of particular interest that anaphylaxis has been observed in patients with common variable immunodeficiency (CVID) who are receiving intravenous gammaglobulin (IVIG), and in that, although these patients have an impaired response
Sharon Julie, Williams, Sudhir, Gupta
openaire +2 more sources
New England Journal of Medicine, 2012
Intravenous immune globulin (IVIG) is therapeutic in a number of situations. However, it contains antibodies that may react with the recipient's tissues to produce a variety of autoimmune manifestations. Hemolytic anemia is a dramatic, but rare sequela of IVIG administration.
Sofya, Pintova +2 more
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Intravenous immune globulin (IVIG) is therapeutic in a number of situations. However, it contains antibodies that may react with the recipient's tissues to produce a variety of autoimmune manifestations. Hemolytic anemia is a dramatic, but rare sequela of IVIG administration.
Sofya, Pintova +2 more
openaire +2 more sources
International Immunopharmacology, 2013
In this study, we evaluated the possibility of using cationized IVIg (cIVIg) instead of IVIg as a more effective therapy for the treatment of experimental immune thrombocytopenia in mice. The pharmacokinetics (PK) and biodistribution of cIVIg and IVIg in mice were compared.
Patrick, Trépanier +2 more
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In this study, we evaluated the possibility of using cationized IVIg (cIVIg) instead of IVIg as a more effective therapy for the treatment of experimental immune thrombocytopenia in mice. The pharmacokinetics (PK) and biodistribution of cIVIg and IVIg in mice were compared.
Patrick, Trépanier +2 more
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Mechanisms of immune regulation by IVIG
Current Opinion in Allergy & Clinical Immunology, 2014In the past few years there have been many advances in our understanding of the mechanisms by which intravenous immune globulin (IVIG) modulates immune function in autoimmune disorders.Previous investigations have focused on the Fc domain of the IgG molecule, and the role of the FcγRIIB receptor and the sialylated Fc domain that have been show to ...
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Mechanism of action of IVIG in ITP
Vox Sanguinis, 2002ABSTRACTIVIG is prepared from large pools of plasma from healthy donors and the IgG is present predominantly in monomeric form. It was first reported in 1981 by Dr. Paul Imbach that high doses of IVIG promote fast recovery of ITP in children [1]. Despite extensive clinical use in a variety of autoimmune and inflammatory states, the mechanism of action ...
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Neurology, 2007
IV immunoglobulin (IVIG) is a widely accepted treatment for autoimmune myasthenia gravis (MG), usually utilized in rapidly progressive or exacerbating disease.1 As with many MG treatments, evidence-based support of its efficacy is scarce and not entirely definitive.
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IV immunoglobulin (IVIG) is a widely accepted treatment for autoimmune myasthenia gravis (MG), usually utilized in rapidly progressive or exacerbating disease.1 As with many MG treatments, evidence-based support of its efficacy is scarce and not entirely definitive.
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Intravenous Immunoglobulin (IVIG)
Intravenous immunoglobulin (IVIG) is a concentrate of immunoglobulins (Ig) prepared from more than 1000 healthy donor sera and contains more than 90% IgG, although there are differences depending on the manufacturer. Although the mechanism of action of IVIG is not clearly known, it is thought to act through multiple mechanisms given its multiple anti ...Salim Mısırcı, Burcu Yağız
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