Results 201 to 210 of about 19,209,998 (295)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Globalization of Perturbative Chern-Simons Theory on the Moduli Space of Flat Connections in the BV Formalism. [PDF]

Commun Math Phys
Mnev P, Wernli K.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Cell Disruption and RNA Extraction from <i>Rhodococcus</i> and <i>Gordonia</i> Bacteria Grown in the Presence of Hydrophobic Organic Compounds and Heavy Metal Salts. [PDF]

Int J Mol Sci
Krivoruchko AV, Komarova LP, Maltseva PY, Tyan SM, Golysheva AA, Plotnitskaya NA, Kuyukina MS, Ivshina IB.   +7 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Mueller manoeuvre increases the mitral-to-aortic velocity-time integral ratio, a mitral regurgitant index, in patients with dilated cardiomyopathy. [PDF]

Clin Physiol Funct Imaging
Virolainen J, Ventilä M, Kupari M.
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Comparative Study of PID and Bio-Inspired Fuzzy Controllers for Speed Regulation of Low-Cost Geared DC Motors. [PDF]

Biomimetics (Basel)
Petrescu I, Băjenaru VD, Popescu DM, Vulturescu V, Ungureanu LM.   +4 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADVANCE-ID bacterial and fungal infections review: antimicrobial resistance research updates. [PDF]

JAC Antimicrob Resist
Manesh A, Mo Y, Wang J, Paterson DL.
europepmc   +1 more source