Results 41 to 50 of about 643,488 (262)
Cumhuriyet İlahiyat Dergisi, 2017 Değerlendirmemize konu olan “What is İslamic Philosophy?” isimli eser, “Doğuşundan Günümüze İslâm Felsefesi” adıyla Türkçe’ye çevrilmiştir. Kitabın hedef kitlesi yazar tarafından Batı’da eğitim gören ve İslam hakkında ya hiçbir şey bilmeyen ya da ...
İrfan Karadeniz
doaj
FEBS Open Bio, EarlyView.The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance
BMC Cancer, 2019 Background Understanding mechanisms underlying specific chemotherapeutic responses in subtypes of cancer may improve identification of treatment strategies most likely to benefit particular patients.
David P. Hill +10 more
doaj +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Electronic Physician, 2017 Background and aim: Test of maximal oxygen consumption is the gold standard for measuring cardio- pulmonary fitness. This study aimed to determine correlation of Gerkin, Queen's College, George, and Jackson methods in estimating maximal oxygen ...
Payam Heydari +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
FASEB BioAdvances, 2022 Although colorectal cancer (CRC) treatment has seen a remarkable improvement in the recent years, many patients will develop metastasis due to the resistance of cancer cells to chemotherapeutics.
Nicole Betson +7 more
doaj +1 more source
Multivariate Jackson Inequality
Journal of Computational and Applied Mathematics, 2009 Let \(E\) be a fat (i.e. \(E=\overline{\text{int}E}\)) compact subset of the space \(\mathbb R^N\). Let \(C^\infty_{\text{int}}(E)\) denote the space of all \(C^\infty\)\;functions in int\,\(E\) which can be continuously extended together with all their partial derivatives to \(E\). \(E\) is said to have Jackson's property, if for each \(k=0,1, \dots\)
openaire +4 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
Journal of Neuroinflammation, 2019 Background Environmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and inflammation that could impact cognition directly.
Hongtian Yang +5 more
doaj +1 more source