Results 31 to 40 of about 542,494 (262)

Systemic exposure to bacterial amyloid curli alters the gut mucosal immune response and the microbiome, exacerbating Salmonella-induced arthritis

open access: yesGut Microbes, 2023
The Salmonella biofilm-associated amyloid protein, curli, is a dominant instigator of systemic inflammation and autoimmune responses following Salmonella infection.
Shingo Bessho   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Equivalence between various Shape Preserving Approximations of periodic functions

open access: yesResearches in Mathematics
We show that the validity of Jackson-type estimates in comonotone and coconvex approximations of continuous $2\pi$-periodic functions by trigonometric polynomials is equivalent to the validity of the corresponding estimates of approximation by continuous
D. Leviatan, O.V. Motorna, I.O. Shevchuk
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Forward to Jackson!

open access: yesЭпилепсия и пароксизмальные состояния, 2021
The report shows that V.A. Karlov proved at the current level of knowledge the correctness of the ideas of the great English neurologist John Hughlings Jackson, author of works on localization of the projection motor centers of the cerebral cortex, on ...
K. Yu. Mukhin
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Comparação da composição corporal utilizando dobras cutâneas e bioimpedância em adultos jovens

open access: yesRevista Brasileira de Nutrição Esportiva, 2021
A avaliação da composição corporal é de grande importância para que profissionais da área da saúde possam obter informações individuais de qualidade, e assim propor as melhores estratégias para a obtenção dos objetivos.
Jean Carlos Pancine de Oliveira   +2 more
doaj  

Response to Jackson [PDF]

open access: yesThe American Journal of Human Genetics, 2021
Steven J, Micheletti   +2 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Deducción alternativa del teorema de Lifson-Jackson para el estudio de la difusión efectiva unidimensional en canales periódicos

open access: yesEntreciencias: Diálogos en la Sociedad del Conocimiento, 2015
En este trabajo se hace una deducción alternativa de la ecuación de Lifson-Jackson. Esta fórmula permite calcular la difusión de partículas puntuales en canales periódicos, introduciendo de manera explícita la dependencia en la posición del coeficiente ...
Yoshua Chávez Bolaños   +2 more
doaj  

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