Results 191 to 200 of about 2,905,594 (296)

Vendor-specific microbiomes influence oral cancer development and its response to <i>Streptococcus mitis</i> intervention in mice. [PDF]

J Oral Microbiol
El-Hadedy DE, Chen T, Cai KQ, Klein-Szanto AJ, Mu A, Campbell KS, Whelan KA, Al-Hebshi NN.   +7 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Detecting oxidants in muscle <i>in vivo</i>: A perspective on "State of the art <i>in vivo</i> reactive oxygen species measurements in skeletal muscle using fluorescent probes".

Redox Biochem Chem
Jackson MJ.
europepmc   +1 more source

Anterior cruciate ligament injury prevention: who is responsible for implementation and what are the challenges? [PDF]

Bone Jt Open
Super JT, Spalding T, Jackson K, Jackson W, Bowditch M, Bailey M, LaPrade RF, Haddad FS, Murray IR.   +8 more
europepmc   +1 more source

Erasable FAP Targeted Spray‐On Probe for Fluorescence‐Guided Surgery

Advanced Science, EarlyView.
We present the first erasable spray‐on probe for fluorescence‐guided surgery. Following topical delivery, FAP‐FLASH550 targets fibroblast activation protein–expressing stromal cells, delineating tumor margins with high tumor‐to‐background ratios. A 365 nm UV light pulse rapidly erases fluorescent signals through triazene photodegradation and subsequent
Zachary Rabinowitz, Riley J. Deutsch‐Williams, Ralph Weissleder   +2 more
wiley   +1 more source

Longitudinal analysis of lipid mediators in post-tuberculosis lung disease identifies significant differences. [PDF]

PLOS Glob Public Health
Jackson PD, Helwig M, Bbuye M, Freeberg MA, Thatcher TH, Zawedde S, Kirenga B, Worodria W, Maddipati K, Siddharthan T, Reyna J, Sime PJ.   +11 more
europepmc   +1 more source

Tracking of [14C]Polystyrene Nanoplastics in Pregnant Mice

Advanced Science, EarlyView.
This study investigates [14C]polystyrene nanoplastic ([14C]PS) translocation in late‐stage pregnant mice after intranasal (0.5 mg of [14C]PS on GD12, GD14, and GD16, n = 6) and intravenous administration (1.5 mg of [14C]PS on GD16, n = 6). 14C‐radiolabel allows quantitative tracking of unmodified polystyrene nanoplastics.
Olga Khaybullina, Pallavi Sarkhel, Outi M. Keinänen   +2 more
wiley   +1 more source

Examination of social network members' influence on daily drinking: A pilot study. [PDF]

Addict Behav Rep
Meisel MK, Sokolovsky AW, Jackson KM, Forkus SR, Barnett NP.   +4 more
europepmc   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

Chemo-Nonresponsive Telangiectatic Osteosarcoma With Oligometastatic Recurrence Managed With Multimodality Therapy Including Stereotactic Ablative Body Radiotherapy (SABR): A Case Report With a Pathologic Treatment Effect. [PDF]

Cureus
Orr WS, Vijayakumar S, Al Hmada Y, Mobit P, Collier AB, Barr J, De Delva PE, Davis DB, Yang CC, Nittala R.   +9 more
europepmc   +1 more source