Results 211 to 220 of about 1,163,629 (309)

Mechanisms Underlying an Enhanced Navigation-Based Intervention to Improve Timely Adjuvant Therapy: A Secondary Analysis of the NDURE Randomized Clinical Trial. [PDF]

JAMA Otolaryngol Head Neck Surg
Elhage MN, Kistner-Griffin E, DeMass R, Chera BS, Sterba KR, Halbert CH, Hill EG, Nussenbaum B, Alberg AJ, Nguyen MT, Newman JG, Albergotti WG, Kejner AE, Skoner JM, Adilbay D, Bobian M, Harper JL, Kaczmar J, Zimmerman SA, Stewart S, McLeod T, Sandulache VC, Hermandez DJ, Jackson RS, Puram SV, Kahmke R, Osazuwa-Peters N, Jackson G, Wasp GT, Yom SS, Graboyes EM.   +30 more
europepmc   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

The UK's Tobacco and Vapes Act puts the end of smoking within reach, but the job is not done. [PDF]

Lancet Reg Health Eur
Jackson SE, Cheeseman H, Brown J.
europepmc   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Mapping challenges in the delivery of care for primary ciliary dyskinesia: an international survey on barriers and priorities. [PDF]

ERJ Open Res
Rubbo B, Behan L, Newman LM, Coles J, Goodwin J, Hirst RA, Jackson CL, Driessens C, Goutaki M, Kuehni CE, Lucas JS.   +10 more
europepmc   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Hidden toxicities: assessing city-wide contamination by potentially toxic elements from illegal dumping in Jackson, Mississippi. [PDF]

Environ Geochem Health
Walker ED, Klevan C, Mathews K, Mandalapu SV, Nica C, Ibrahim N.   +5 more
europepmc   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Correction: Dietary behaviors, lifestyle habits, food insecurity risk and depressive symptoms among New York City adolescents: a cross-sectional study. [PDF]

BMC Pediatr
Jackson J, Conigliaro T, Fenlon J, Solomon E, Dowling EA, Dreisbach N, Hamwey M.   +6 more
europepmc   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source