Results 141 to 150 of about 179,777 (295)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
ICE JAM EXPERIMENT AND SIMULATION AROUND BRIDGE PIERS [PDF]
, 2019 This study aimed to clarify the phenomenon of ice jams generated around bridge piers. The onedimensional ice jams calculation model was proposed. This model is composed of water flow, ice flow and ice jams.
横山, 洋 +6 more
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Bilik 24 jam tawar keselesaan pembelajaran sepanjang masa [PDF]
, 2020 Bilik 24 Jam di Perpustakaan Universiti Malaysia Pahang (UMP) merupakan ruang yang paling popular dalam kalangan pelajar ...
Iswan Akim, Ismail
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Oxidative stress and endocrine disruption following exposure to Chlorpyrifos [PDF]
Caspian Journal of Health ResearchChlorpyrifos (CPF) is a widely used organophosphate pesticide that has been shown to cause a range of toxic effects, including oxidative stress and endocrine disruption. This review aims to summarize the most recent findings regarding CPF’s toxicological
Mojtaba ehsanifar +2 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
STUDY ON SNOWSTORM-INDUCED INCREASES IN FRAZIL SLUSH AND THE IDENTIFICATION OF POTENTIAL ICE JAM LOCATIONS ON THE OSOBETSU RIVER [PDF]
, 2016 In December 2014, an ice jam occurred on the Osobetsu River after a snowstorm. This study investigated factors that contribute to increases in frazil slush and identified locations prone to ice jams.
船木, 淳悟 +6 more
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International Journal of Economic and Environment GeologyThisexperimentwasconductedatLatifAgricultureFarm,Tandojam,DistrictHyderabadduringRabiseason 2020-2021toassesstheeffectsofzincappliedintheformoffoliaronwheatyieldandgrowthcharacteristics, employingarandomizedcompleteblockdesign(RCBD ...
Muhammad Aslam Panhwar +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Mehran University Research Journal of Engineering and Technology, 2018 An experimental study was carried out on a Lysimeter with the aim of partially meeting WRs (Water Requirements) of the Okra crop through SWT (Shallow Water Table) while maintaining the SWT at various levels below the ground surface. Under the study, CWR (
Nazir Gul +4 more
doaj