Results 31 to 40 of about 87,477 (247)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

ASSESSING WATER CONSUMPTION OF BARLEY CULTIVATION IN THI-QAR PROVINCE, IRAQ [PDF]

Journal CleanWAS, 2017
We assessed the blue and green water consumption for cultivating barley in the Thi-Qar province, Iraq. CROPWAT 8.0 model was used to compute the total crop water use for both crops based on the meteorological data such as rainfall, maximum and minimum ...
Mahmood , Marlia
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

JAMAL BEY ALBOGACHIEV: PUBLIC AND POLITICAL LIFE IN EMIGRATION

Кавказология, 2021
The aim of this article is study social and political activities by ingush Jamal Albogachiev (1894–1949). This is the first study of this person. This article is based on the archives from France and Germany.
I. L. BABICH, J. SCHNELLE
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Jamal Al-Banna’s Perspective on The Understanding Reconstruction of Changing Munkar: Decolonization of the Study of Islamic Thought From Textual to Contextual Knowledge

Millati: Journal of Islamic Studies and Humanities, 2022
Changing munkar (doing evil) is one of the crucial and important themes to be discussed, especially when it comes to the religion, it will be even more sensitive.
ABDUL MUFID
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Outbreak of Meningitis in Iraq in 2023

Global Pediatric Health
Objective . To determine clinical presentations and laboratory findings of meningitis outbreak among children in 2023 in Iraq. Method . the demographic data (gender, age, symptoms, and disease transmission among family members) were collected from child ...
Khalid Hama Salih MBChB, DCH, FIBMS-ped, Zana Baqi Najmadden MBChB, CABP, Bahadin Qader Ahmed MBChB, FKBMS, Pishdar Abdullah Ismael MBChB, FKBMS, Kaiwan H. Kareem MBChB, Lana Diyar Abdulqadir MBChB, Roza M. Sabir MBChB, Basta J. Abdalla MBChB, Binay A. Qadir MBChB, Razhan M. Mohammed MBChB, Ali Salih karim MBChB   +10 more
doaj   +1 more source

Algorithm Approaches for Shortest Path Problem in an Interval - Valued Triangular Pythagorean Fuzzy Network

Ratio Mathematica, 2023
It has been proposed to use Pythagorean fuzzy sets (PFS), is an extension of fuzzy sets (FSs), to address uncertainty in practical decision – making problems.
Asim Basha M, Mohammed Jabarulla M
doaj   +1 more source