Results 21 to 30 of about 3,588,451 (257)

Monte Carlo Spectral Integration: a Consistent Approximation for Radiative Transfer in Large Eddy Simulations

Journal of Advances in Modeling Earth Systems, 2009
Large-eddy simulation (LES) refers to a class of calculations in which the large energy-rich eddies are simulated directly and are insensitive to errors in the modeling of sub-grid scale processes.
Robert Pincus, Bjorn Stevens
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Comparison of Explicitly Simulated and Downscaled Tropical Cyclone Activity in a High-Resolution Global Climate Model

Journal of Advances in Modeling Earth Systems, 2010
The response of tropical cyclone activity to climate change is a matter of great inherent interest and practical importance. Most current global climate models are not, however, capable of adequately resolving tropical cyclones; this has led to the ...
Hirofumi Tomita, Masaki Satoh, Yohei Yamada, Kazuyoshi Oouchi, Kerry Emanuel   +4 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Application of the Concepts of Rossby Length and Rossby Depth to Tropical Cyclone Dynamics

Journal of Advances in Modeling Earth Systems, 2010
This paper examines the usefulness of the complementary concepts of Rossby length and Rossby depth.  These concepts are discussed in the context of idealized analytical solutions of the transverse circulation equation that arises in the balanced vortex ...
Wayne H Schubert, Brian D McNoldy
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Rotated Versions of the Jablonowski Steady-State and Baroclinic Wave Test Cases: A Dynamical Core Intercomparison

Journal of Advances in Modeling Earth Systems, 2010
The Jablonowski test case is widely used for debugging and evaluating the numerical characteristics of global dynamical cores that describe the fluid dynamics component of Atmospheric General Circulation Models.
Ramachandran D Nair, Mark A Taylor, Christiane Jablonowski, Peter Hjort Lauritzen   +3 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

With regard to persons: Divine election of the poor in James and Paul

In die Skriflig
Traditionally, Reformed accounts of divine election presuppose that God elects without regard to persons. As a result, they cannot fully accommodate the biblical motif of God’s choice for the poor.
Pieter Dirk Dekker
doaj   +1 more source

Surface Fluxes and Tropical Intraseasonal Variability: a Reassessment

Journal of Advances in Modeling Earth Systems, 2010
The authors argue that interactive feedbacks involving surface moist enthalpy fluxes, both turbulent and radiative, are important to the dynamics of tropical intraseasonal variability.
Adam H Sobel, Gilles Bellon, Eric D Maloney, Dargan M. Frierson   +3 more
doaj   +1 more source