Results 21 to 30 of about 814,808 (161)

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

open access: yesiScience, 2021
Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of ...
Thushan I. de Silva   +1012 more
doaj   +1 more source

Global Current Practice Patterns for the Management of Hyphema

open access: yesClinical Ophthalmology, 2022
Sarah C Miller,1 Prajna Meeralakshmi,2 Michael J Fliotsos,3 Grant A Justin,4 Yoshihiro Yonekawa,5 Ariel Chen,1 Annette K Hoskin,6,7 Richard J Blanch,8– 10 Kara M Cavuoto,11 Rebecca Low,12 Ximin Li,1,13 Matthew Gardiner,14 TY Alvin Liu,1 Ankoor S Shah,14 ...
Miller SC   +16 more
doaj  

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

open access: yesNature Communications, 2020
Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes ...
Emily E. Burke   +36 more
doaj   +1 more source

A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

open access: yesBreast Cancer Research, 2023
Background Genome-wide studies of gene–environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures.
Pooja Middha   +134 more
doaj   +1 more source

Managing work flow in high enrolling trials: The development and implementation of a sampling strategy in the PREPARE trial

open access: yesContemporary Clinical Trials Communications, 2021
Introduction: Pragmatic trials in comparative effectiveness research assess the effects of different treatment, therapeutic, or healthcare options in clinical practice.
David Pogorzelski   +384 more
doaj   +1 more source

Management and early outcomes of children with appendicitis in the UK and Ireland during the COVID-19 pandemic: a survey of surgeons and observational study

open access: yesBMJ Paediatrics Open, 2020
Objectives Acute appendicitis is the most common surgical condition in children. In the UK, appendicectomy is the most common treatment with non-operative management unusual.
Nigel J Hall   +190 more
doaj   +1 more source

Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials

open access: yesContemporary Clinical Trials Communications, 2021
Introduction: Cluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional model of obtaining informed consent from participant's before initiating any trial related activities may not ...
Guillermo Pechero, Jr., MD   +399 more
doaj   +1 more source

Encountering China: the evolution of Timothy Richard's missionary thought (1870-1891) [PDF]

open access: yes, 2019
In pursuit of the conversion of others, cross-cultural missionaries often experience their own “conversions.” This thesis explores the ways in which one particular missionary, the Welshman Timothy Richard (1845–1919), was transformed by his encounter ...
Ireland, Daryl
core  

Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response

open access: yesMetabolites
A multimodal mass spectrometry imaging (MSI) approach was used to investigate the chemotherapy drug-induced response of a Multicellular Tumour Spheroid (MCTS) 3D cell culture model of osteosarcoma (OS). The work addresses the critical demand for enhanced
Sophie M. Pearce   +9 more
doaj   +1 more source

Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study

open access: yesBMJ Open
Background Prostate cancer (PCa) is the most common male malignancy in the western world. Many men (40%) are diagnosed with localised low or intermediate-risk PCa, which is suitable for active surveillance (AS).
Samuel Smith   +14 more
doaj   +1 more source

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