Results 81 to 90 of about 9,067 (287)

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Mainlobe and sidelobe jamming suppression method based on distributed array radar with eigen‐projection matrix processing and null constraints

IET Radar, Sonar & Navigation
The jamming in electronic warfare environment significantly degrades the performance of the radar system, especially the mainlobe jamming. The distributed array radar can suppress the mainlobe jamming by increasing the array aperture with auxiliary ...
Bowen Han, Xiaopeng Yang, Qiang Lv, Wolin Li, Zhengyan Zhang, Shichao Zhong   +5 more
doaj   +1 more source

Intelligent ECCM technology via cognition and agility for the airborne radar

The Journal of Engineering, 2019
The electronic counter countermeasures (ECCM) technology is crucial to the modern airborne radar. In this study, opposed to the intelligent electronic countermeasure system, an intelligent anti-jamming technology is developed, which adjusts the working ...
Luo Meifang, Hao Zhimei, Zhu Yimin
doaj   +1 more source

Packing Hyperspheres in High-Dimensional Euclidean Spaces

, 2006
We present the first study of disordered jammed hard-sphere packings in four-, five- and six-dimensional Euclidean spaces. Using a collision-driven packing generation algorithm, we obtain the first estimates for the packing fractions of the maximally ...
Donev, A., Skoge, M., Stillinger, F. H., Torquato, S.   +3 more
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Suppression Approach to Main-Beam Deceptive Jamming in FDA-MIMO Radar Using Nonhomogeneous Sample Detection

IEEE Access, 2018
Suppressing the main-beam deceptive jamming in traditional radar systems is challenging. Furthermore, the observations corrupted by false targets generated by smart deceptive jammers, which are not independent and identically distributed because of the ...
Lan Lan, Guisheng Liao, Jingwei Xu, Yuhong Zhang, Francesco Fioranelli   +4 more
doaj   +1 more source

Critical slowing down and hyperuniformity on approach to jamming

, 2016
Hyperuniformity characterizes a state of matter that is poised at a critical point at which density or volume-fraction fluctuations are anomalously suppressed at infinite wavelengths.
Atkinson, Steven, Hopkins, Adam B., Torquato, Salvatore, Zhang, Ge   +3 more
core   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

ICCA: Independent Multi-Agent Algorithm for Distributed Jamming Scheduling

Algorithms
In extreme scenarios, to prevent the leakage of jamming coordination information, the jammers must proactively terminate their communication functions and implement jamming resource scheduling via Non-Networked Cooperation.
Wenpeng Wu, Zhenhua Wei, Haiyang You, Zhaoguang Zhang, Chenxi Li, Jianwei Zhan, Shan Zhao   +6 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source