Results 91 to 100 of about 146,483 (344)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Criterion for traffic phases in single vehicle data and empirical test of a microscopic three-phase traffic theory

, 2005
A microscopic criterion for distinguishing synchronized flow and wide moving jam phases in single vehicle data measured at a single freeway location is presented.
Andreas Hiller, Banks J, Boris S Kerner, Bovy P H L, Fukui M Sugiyama Y Schreckenberg M Wolf D E, Gartner N H, Gurusinghe G S Nakatsuji T Azuta Y Ranjitkar P Tanaboriboon Y, Helbing D, Hoogendoorn S P Luding S Bovy P H L Schreckenberg M Wolf D E, Jiang R, Kerner B S, Kerner B S, Kerner B S, Kerner B S, Kerner B S Klenov S L Hiller A, Knospe W, Koshi M Iwasaki M Ohkura I Hurdle V F, Luttinen T, Mahmassani H S, Nagatani T, Sergey L Klenov, Tilch B Helbing D Helbing D Herrmann H J Schreckenberg M Wolf D E, Wagner P Fukui M Sugiyama Y Schreckenberg M Wolf D E, Wagner P Lubashevsky I   +23 more
core   +1 more source

Origin of Two Distinct Stress Relaxation Regimes in Shear Jammed Dense Suspensions [PDF]

, 2022
Sachidananda Barik, Sayantan Majumdar
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Texture, Color, and Sensory Features of Low-Sugar Gooseberry Jams Enriched with Plant Ingredients with Prohealth Properties

Journal of Food Quality, 2018
The aim of this research was to evaluate texture, color, and sensory parameters of low-sugar gooseberry jams with added black chokeberry, elderberry, Japanese quince, flax seeds, wheat germ, and inulin.
Anna Banaś, Anna Korus, Jarosław Korus
doaj   +1 more source

Soyuz 22 Return Samples: Assessment of Air Quality Aboard the International Space Station [PDF]

Three mini-grab sample containers (m-GSCs) were returned aboard Soyuz 22 because of concerns that new air pollutants were present in the air and these were getting into the water recovery system.
Jams, John T.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Self-Organized Criticality and $1/f$ Noise in Traffic

, 1995
Phantom traffic jams may emerge ``out of nowhere'' from small fluctuations rather than being triggered by large, exceptional events. We show how phantom jams arise in a model of single lane highway traffic, which mimics human driving behavior ...
Nagel, Kai, Paczuski, Maya
core   +2 more sources