Results 111 to 120 of about 146,483 (344)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Open-Access Anime: The Magnificent Continuation of JAMS’ Magical Girl Transformation
Journal of Anime and Manga Studies, 2022 Billy Tringali
doaj +1 more source
Statistical Physics of Vehicular Traffic and Some Related Systems
, 2000 In the so-called "microscopic" models of vehicular traffic, attention is paid explicitly to each individual vehicle each of which is represented by a "particle"; the nature of the "interactions" among these particles is determined by the way the vehicles
Chowdhury, Debashish +2 more
core +3 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Human behavior as origin of traffic phases
, 2001 It is shown that the desire for smooth and comfortable driving is directly responsible for the occurrence of complex spatio-temporal structures (``synchronized traffic'') in highway traffic. This desire goes beyond the avoidance of accidents which so far
Andreas Schadschneider +19 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Jam Tomorrow, Jam Yesterday, but Never Jam Today: Some Modest Proposals for Venturing Through the Looking-Glass of Scholarly Communication [PDF]
The Serials Librarian, 1998 In the past, scholarly publishing grew in support of college and university needs to support the peer review tenure and promotion system, which itself developed to encourage the learning process through the generation of new knowledge. However, the continuation of this system of scholarly communications is threatened today by internal and external ...
openaire +1 more source