Results 61 to 70 of about 146,483 (344)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Pengolahan dan Pemanfaatan Buah Merah dalam Upaya Pengentasan Kemiskinan

open access: yesJurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement), 2019
Processing and utilization program of red fruit in Yiwika Village are based on the reality that the people of Yiwika Village still cannot escape from the poverty. One of the great untapped potentials in Yiwika Village is the red fruit.
Bhaskara Anggarda Gathot Subrata   +2 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Redundant screwjack [PDF]

open access: yes, 1973
Device uses differential gears to drive either one of two nut-screw assemblies. In event that one assembly jams, second assembly is driven at twice its normal rate with no loss in overall ...
Benjamin, R. W.
core   +1 more source

Deterministic Models for Traffic Jams

open access: yes, 1993
We study several deterministic one-dimensional traffic models. For integer positions and velocities we find the typical high and low density phases separated by a simple transition.
Bak   +16 more
core   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Fenomena Lalu Lintas Simpang Bersinyal di Kota Bekasi (Studi Kasus: Simpang Tol Bekasi Timur)

open access: yesJurnal Pembangunan Wilayah dan Kota, 2016
The transportation’s problem that common in Indonesia is a limitation of road space and intersection that needed to conduct the traffic flow. An accident and degradation of intersection’s performance, it’s caused by the driver’s attitude which have a ...
Yuanda Patria Tama
doaj   +1 more source

Quality of Clementine Jam Influenced by Purée Pretreatment, Sugar Type and Pectin Addition [PDF]

open access: yes, 2009
The aim of this research was to investigate the influence of several parameters on quality of Clementine (Citrus clementine) jam. Thermal treated and nontreated Clementine purée, two types of sugar (sucrose and fructose) and three different amounts of ...
Branka Levaj   +5 more
core   +1 more source

Will jams get worse when slow cars move over?

open access: yes, 2005
Motivated by an analogy with traffic, we simulate two species of particles (`vehicles'), moving stochastically in opposite directions on a two-lane ring road.
B Schmittmann   +10 more
core   +2 more sources

Role of vibrations in the jamming and unjamming of grains discharging from a silo [PDF]

open access: yes, 2009
We present experimental results of the jamming of non-cohesive particles discharged from a flat bottomed silo subjected to vertical vibration. When the exit orifice is only a few grain diameter wide, the flow can be arrested due to the formation of ...
Garcimartin, Angel   +4 more
core   +2 more sources

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