Results 71 to 80 of about 146,483 (344)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Chuck for delicate drills [PDF]

open access: yes, 1972
Development of oil film technique to couple power between drive spindle and drill chuck for delicate drilling operations is discussed. Oil film permits application of sufficient pressure, but stops rotating when drill jams.
Copeland, C. S.
core   +1 more source

Entropy of Jammed Matter [PDF]

open access: yesPhysical Review Letters, 2008
5 pages, 1 ...
Briscoe, Christopher   +3 more
openaire   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Traffic jams and intermittent flows in microfluidic networks

open access: yes, 2010
We investigate both experimentally and theoretically the traffic of particles flowing in microfluidic obstacle networks. We show that the traffic dynamics is a non-linear process: the particle current does not scale with the particle density even in the ...
Adrien Montourcy   +7 more
core   +1 more source

Evolutionary pressures on the yeast transcriptome [PDF]

open access: yes, 2015
Codon usage bias (CUB) is the well known phenomenon that the frequency of synonymous codons is unequal. This is presumably the result of adaptive pressures favouring some codons over others.
Chu, Dominique, Salykin, Anton
core   +1 more source

JAMming the signals [PDF]

open access: yesBlood, 2012
In this issue of Blood, Naik and colleagues have identified a new mechanism used by platelets to inhibit the signals that drive their activation through integrin αIIbβ3,which serves to prevent inappropriate or premature thrombus formation.
openaire   +2 more sources

Jamming in granular polymers [PDF]

open access: yesPhysical Review E, 2011
5 pages, 7 postscript figures, version to appear in ...
Lopatina, L. M.   +2 more
openaire   +3 more sources

Home - About - Disclaimer - Privacy