Results 81 to 90 of about 81,723 (303)

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]

, 2018
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P., Donaghy, Dillon, Gibbins, Jonathan M., Kriek, Neline, Osborne, Ashley A., Sage, Tanya, Unsworth, Amanda J.   +6 more
core   +4 more sources

The Burden of Alopecia Areata and Management with Baricitinib in the United Arab Emirates: A Narrative Review

Dermatology and Therapy
Alopecia areata is an inflammatory autoimmune disease that presents as non-scarring hair loss in adults and children and causes substantial psychological distress, economic burden, and reduced quality of life for those affected.
Hussein Abdel Dayem, Anwar Al Hammadi, Ashraf Reda, Fatima Albreiki, Ayman Al Naeem, Ahmed Ameen, Mohamed Ahmed, Huda Rajab Ali, Mohamed Elrayes, Gozde Senay, Muna Al Murrawi   +10 more
doaj   +1 more source

JAK inhibitors for the treatment of juvenile localized scleroderma: a case report and literature review

Pediatric Rheumatology Online Journal
Background Juvenile localized scleroderma (JLS) is a chronic autoimmune and fibrosing disease that can cause significant damage and impairments. Currently, management of JLS is challenging due to the paucity of antifibrotic drugs. In patients with severe
Rongjun Zheng, Lixia Zou, Suzanne C. Li, Meiping Lu   +3 more
doaj   +1 more source

The specificities of small molecule inhibitors of the TGF beta and BMP pathways [PDF]

, 2011
Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators of TGF beta and BMP signals, have been employed extensively to assess their physiological roles in cells and organisms. While all of these inhibitors have been
Sapkota, Gopal P., Traynor, Ryan, Vogt, Janis   +2 more
core   +3 more sources

Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing [PDF]

, 2020
Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing.
Brinkman, Antonia Clara Katharina, Burmester, Gerd-Rüdiger, Buttgereit, Frank, Damerau, Alexandra, Diesing, Karoline, Gaber, Timo, Hoff, Paula, Lang, Annemarie, Ohrndorf, Sarah, Pfeiffenberger, Moritz, Pienczikowski, Justyna   +10 more
core   +1 more source

Efficacy and Safety of Guselkumab in Participants With Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of a Phase 3, Randomized, Placebo‐Controlled Study

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the efficacy and safety of guselkumab, an interleukin‐23p19 subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor (TNF) inhibitor.
Alexis Ogdie, Joseph F. Merola, Philip J. Mease, Christopher T. Ritchlin, Jose U. Scher, Kimberly Parnell Lafferty, Daphne Chan, Soumya D. Chakravarty, Wayne Langholff, Yanli Wang, Jie Shao, Yevgeniy Krol, Alice B. Gottlieb   +12 more
wiley   +1 more source

Determinants of Difficult‐to‐Manage and Treatment‐Refractory Axial Spondyloarthritis: A Cross‐Sectional Analysis within a Longitudinal Cohort

Arthritis &Rheumatology, Accepted Article.
Objective To estimate the prevalence of difficult‐to‐manage (D2M) and treatment‐refractory (TR) axSpA and to identify factors associated with D2M/TR disease in a longitudinal cohort. Methods We performed a cross‐sectional analysis on data from the Schroeder Arthritis Institute Spondylitis Program cohort.
Patricia Remalante‐Rayco, Laura Passalent, Tina Chim, Hannah Vijayan, Manal Alnasser, Zeynep Baskurt, Robert D. Inman, Nigil Haroon, Denis Poddubnyy   +8 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Successful treatment of airborne allergic dermatitis to sesquiterpene lactone with upadacitinib: A case report

SAGE Open Medical Case Reports
This case report describes, to our knowledge, the first known successful treatment of airborne allergic contact dermatitis to sesquiterpene lactone with upadacitinib in an adult patient.
Barbara Marzario, Daniela Cino, Sophia Colantonio   +2 more
doaj   +1 more source

Machine learning-based prediction of response to Janus kinase inhibitors in patients with rheumatoid arthritis using clinical data

Frontiers in Immunology
ObjectiveRheumatoid arthritis (RA) is a chronic inflammatory disease with considerable heterogeneity in treatment response, leaving many patients unable to achieve remission or low disease activity. We aimed to develop a machine learning model to predict
Yeo-Jin Lee, Gyucheol Choi, Joongyeub Yeo, Jiyeong Baek, Heeju Choi, Minji Kim, Yong-Gil Kim, Bo Young Kim, Jamin Koo, Jamin Koo, Jamin Koo   +10 more
doaj   +1 more source