Results 51 to 60 of about 5,587,857 (353)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Paracoccidioidomycosis in Japan.
Nihon Naika Gakkai Zasshi, 1987 中南米の風土病であるParacoccidioidomycosisの自験例を報告し,本邦における症例についての文献的考察を加える.患者は34才の日本人女性で5年間のブラジル在住歴があり,発熱,全身リンパ節腫大,体重減少等の症状を呈し,肝,脾,骨への病変の広がりを認めた.このなかで肺病変がなく,全身のリンパ節腫大と骨病変を生じたことが本症としては非定型的であった.リンパ節組織所見,培養および血清学的検査にて診断が確定し, amphotericinBとketoconazoleによる約2年間の治療にて完治した. Paracoccidioidomycosisの本邦における報告例はこれまでに5例を数えるのみにすぎないが,国際化の波と共に本疾患に遭遇する可能性が増すことを銘記されたい.
CHIKAMORI, Taishiro +3 more
openaire +3 more sources
Digestion, 2019 Colonic diverticular disease has been increasing in prevalence in Japan due to the rapidly aging population. Colonic diverticular bleeding can result in hemorrhagic shock requiring blood transfusion, and it carries a high risk of recurrence within 1 year.
N. Nagata +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Citizen Participation in Governmental Decision Making in Japan: A Review [PDF]
, 2015 Over the past decade citizens have become much more involved in several aspects of policy-making and governance. Public participation in decision-making is seen to generate more accountability, better performance, strengthening of democracy, and counters
720, 721, Gurtoo, Anjula
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Japan-U.S. Joint Message on Climate Change Negotiations [PDF]
, 2009 A joint message on Climate Change Negotiations between Japan and U ...
Japan. Gaimushō.
core
Thoracic and cardiovascular surgeries in Japan during 2017
General Thoracic and Cardiovascular Surgery, 2020 Committee for Scientific Affairs, The Japanese Association for Thoracic Surgery · Hideyuki Shimizu · Morihito Okada · Akira Tangoku · Yuichiro Doki · Shunsuke Endo · Hirotsugu Fukuda · Yasutaka Hirata · Hisashi Iwata · Junjiro Kobayashi · Hiraku Kumamaru
H. Shimizu +27 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source