Results 61 to 70 of about 108,229 (284)

Japanese Encephalitis Virus Induces Apoptosis and Encephalitis by Activating the PERK Pathway

Journal of Virology, 2019
Japanese encephalitis virus (JEV) infection triggers endoplasmic reticulum (ER) stress and neuron apoptosis. ER stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) has been reported to induce apoptosis under acute or prolonged ER ...
Qianruo Wang, Xiu Xin, Ting Wang, Jiawu Wan, Yangtao Ou, Zibing Yang, Q. Yu, Liting Zhu, Yunli Guo, Yinsheng Wu, Zhen Ding, Yan-ni Zhang, Z. Pan, Yuxin Tang, Shanshan Li, Lingbao Kong   +15 more
semanticscholar   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Culex tarsalis is a competent vector species for Cache Valley virus [PDF]

, 2018
Background: Cache Valley virus (CVV) is a mosquito-borne orthobunyavirus endemic in North America. The virus is an important agricultural pathogen leading to abortion and embryonic lethality in ruminant species, especially sheep.
Alto, Barry W., Ayers, Victoria B., Blitvich, Bradley J., Dunlop, James I., Higgs, Stephen, Huang, Yan-Jang, Kohl, Alain, Lyons, Amy C., Park, So Lee, Unlu, Isik, Vanlandingham, Dana L.   +10 more
core   +1 more source

Minimally Clinically Important Difference of the Clinical Assessment Scale in Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The Clinical Assessment Scale in Autoimmune Encephalitis (CASE) tracks disease severity in autoimmune encephalitis (AE), but no threshold for significant change exists. We aimed to determine the minimally clinically important difference (MCID) for CASE.
Yihui Goh, Yoon Hee Shin, Soo Hyun Ahn, Su Yee Mon, Soo Jean Shin, Woo‐Jin Lee, Yoonhyuk Jang, Myoung‐Jin Jang, Soon‐Tae Lee   +8 more
wiley   +1 more source

Fatal Infection with Murray Valley Encephalitis Virus Imported from Australia to Canada, 2011

Emerging Infectious Diseases, 2017
Murray Valley encephalitis virus (MVEV), a flavivirus belonging to the Japanese encephalitis serogroup, can cause severe clinical manifestations in humans.
Daniel J. Niven, Kevin Afra, Mircea Iftinca, Raymond Tellier, Kevin Fonseca, Andreas Kramer, David Safronetz, Kimberly Holloway, Michael Drebot, Andrew S. Johnson   +9 more
doaj   +1 more source

Acute encephalitis syndrome surveillance, Kushinagar district, Uttar Pradesh, India, 2011-2012 [PDF]

, 2013
In India, quality surveillance for acute encephalitis syndrome (AES), including laboratory testing, is necessary for understanding the epidemiology and etiology of AES, planning interventions, and developing policy.
Arunachalam, Beig, Bhatt, Elizabeth T. Rogawski, German RR, Lee LM, Horan JM, Milstein RL, Pertowski CA, Waller MN, Hills, Karmarkar, Kumar, Lewthwaite, Manish Kakkar, Parida, Roy, Sampath K. Krishnan, Samuel, Sanjay Chaturvedi, Sapkal, Sarkari, Saxena, Shaikh Shah Hossain, Syed Shahid Abbas, Tapan N. Dhole   +20 more
core   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Clinical profile and outcome of acute encephalitis syndrome (AES) patients treated in College of Medical Sciences-Teaching Hospital

Journal of College of Medical Sciences-Nepal, 2014
Objective: Acute encephalitis syndrome is a cause of significant morbidity and mortality in Nepal. Although Japanese encephalitis virus (JEV) was thought to be a major cause for acute encephalitis syndrome, more non-Japanese encephalitis virus cases
Lekhjung J Thapa, RS Twayana, R Shilpakar, MR Ghimire, A Shrestha, S Sapkota, PVS Rana   +6 more
doaj   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Zika virus infection: a public health emergency! [PDF]

, 2017
Zika virus belongs to the family of Flaviviridae. The Flaviviridae family also includes other human pathogens like West Nile virus (WNV), Yellow fever virus (YFV), mosquito transmitted Dengue virus (DENV), Tick borne encephalitic virus (TBEV) and ...
Khan, Ramsha, Qureshi, Bakhtawar Wajeeha, Qureshi, Muhammad Salman Haider   +2 more
core   +1 more source