Results 231 to 240 of about 17,397,157 (307)

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

The history of the Japanese Society for Neuro-infectious Diseases: Foundation, objectives, and legacy. [PDF]

Intractable Rare Dis Res
Shoji H, Yamano Y.
europepmc   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Statement on medication simplification in long-term care facilities by the Japanese Society of Geriatric Pharmacy: English translation of the Japanese article. [PDF]

Geriatr Gerontol Int
Maruoka H, Hamada S, Koujiya E, Higashihara K, Shinonaga H, Arai K, Saotome S, Okura T, Mizokami F, Okochi J, Takeya Y, Kurata N, Akishita M, Japanese Society of Geriatric Pharmacy Working Group on Medication Simplification in Long‐term Care Facilities.   +13 more
europepmc   +1 more source

Shear‐Mode Direct Piezoelectric Response of Ferroelectric Nematic Liquid Crystals

Advanced Science, EarlyView.
Periodic shear‐induced electric current measurements are reported on two archetypic ferroelectric nematic liquid crystal compounds. From the temperature, frequency and shear angle dependent results of the first and second harmonic current signals together with temperature and oscillatory rheology measurements, the effective piezoelectric coupling ...
Péter Salamon, Marcell Tibor Máthé, Hiroya Nishikawa, Fumito Araoka, Antal Jákli   +4 more
wiley   +1 more source

Lack of women physician representation in the Japanese Society of Hospital General Medicine. [PDF]

J Gen Fam Med
Shiota S, Utsunomiya-Nishimizu R, Goto R, Hirabayashi A, Horinouchi N, Doi E, Yoshimura K, Yamamoto K, Yoshiiwa A, Miyazaki E.   +9 more
europepmc   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

Consensus statement on "Oral frailty" from the Japan Geriatrics Society, the Japanese Society of Gerodontology, and the Japanese Association on Sarcopenia and Frailty. [PDF]

Geriatr Gerontol Int
Tanaka T, Hirano H, Ikebe K, Ueda T, Iwasaki M, Minakuchi S, Arai H, Akishita M, Kozaki K, Iijima K.   +9 more
europepmc   +1 more source

Solvent‐Desorption‐Induced Formation of a Long‐Period Polymorph Yielding a High‐Performance Porphyrin‐Based Organic Semiconductor

Advanced Science, EarlyView.
Solvent‐desorption‐induced structural transformation of 5,15‐bisphenyl‐tetrabenzoporphyrin generates a long‐period polymorph, in which the π‐stacking direction rotates by 90° between adjacent layers within the crystal while largely retaining crystallographic integrity.
Kazuya Miyazaki, Keitaro Yamamoto, Mitsuaki Yamauchi, Yoshiyuki Mizuhata, Hiroshi Matsuda, Nobutaka Shioya, Takeshi Hasegawa, Hiroko Yamada   +7 more
wiley   +1 more source

A Risk Analysis for Ischemic Necrosis of the Remnant Stomach After Distal Pancreatectomy in Patients With Previous Distal Gastrectomy: A Multicenter Retrospective Survey by the Japanese Society of Pancreatic Surgery. [PDF]

J Hepatobiliary Pancreat Sci
Kishi T, Tajima Y, Hayashi H, Kawabata Y, Uemura K, Nagai M, Nishio K, Fukuzawa K, Yagi S, Hidaka M.   +9 more
europepmc   +1 more source