Results 81 to 90 of about 2,335 (170)

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

Diagnosing and reintegrating traceability of infectious diseases via metagenomic next-generation sequencing: Study of a severe case of Rickettsia japonica infection

Infectious Medicine
Background: In this study, we present a case of Japanese spotted fever (JSF) caused by Rickettsia japonica and use this case to investigate the process of diagnosing and reintegrating traceability of infectious diseases via metagenomic next-generation ...
Zhenhua Lu, Jing Han, Yuanyuan Wang, Zhen He, Shuxuan Song, Kun Liu, Zhongjun Shao   +6 more
doaj   +1 more source

Serological Cross-Reactivity among Orientia tsutsugamushi Serotypes but Not with Rickettsia japonica in Japan

Tropical Medicine and Infectious Disease, 2018
The rickettsial diseases Japanese spotted fever (JSF) and scrub typhus (ST) are caused by Rickettsia japonica and Orientia tsutsugamushi, respectively. The diseases share clinical symptoms, such as fever, rash, and eschar.
Eiichiro Sando, Koya Ariyoshi, Hiromi Fujita   +2 more
doaj   +1 more source

OVERVIEW OF TICK-ASSOCIATED RICKETTSIALES BACTERIA IN JAPAN

Acta Biomedica Scientifica, 2012
Rickettsiales bacteria are obligatory intracellular parasites in vertebrates and/or invertebrates, and some cause severe febrile illness in humans as well as livestock.
N. .. Ohashi, Y. .. Yoshikawa, T. .. Masuzawa   +2 more
doaj  

Japanese spotted fever [PDF]

QJM: An International Journal of Medicine, 2019
A, Nakanishi, K, Harada, S, Ota, E, Miyasaka   +3 more
openaire   +2 more sources

Pharmacy‐Based Immunization Delivery: A Comprehensive History and Current Challenges

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 6, June 2026.
ABSTRACT Pharmacists and their teams have a long history of involvement with vaccines. This paper describes the contributions of pharmacy‐based immunization delivery in the United States from the 1800's to date. Early activities centered around storage and distribution of antitoxins and vaccines. From the 1950s through the early 1990s, pharmacists were
Jean‐Venable R. Goode, Mitchel C. Rothholz, Stephan L. Foster, Erica R. Brody, John D. Gräbenstein   +4 more
wiley   +1 more source

Japanese spotted fever [PDF]

QJM: An International Journal of Medicine, 2018
H, Matsuura, K, Yamauchi, K, Kagawa, F, Zheng   +3 more
openaire   +2 more sources

A Case of Japanese Spotted Fever with Extreme Vasculitis

Nishi Nihon Hifuka, 2009
49歳の男性, 千葉県在住。初診の10日前に養鶏場の大掃除をした。7日前より38℃以上の発熱と全身の紅斑が認められ, 当科受診した。刺し口を疑う皮疹は認められなかったが, 高熱が続き, 腎機能障害も認められたため, リケッチア症の可能性を考え, 塩酸ミノサイクリン200mg/dayを内服したところ速やかに解熱した。日本紅斑熱抗原に対する抗体価はIgM, IgGともに160倍以上に上昇しており, 日本紅斑熱と診断した。紅斑部の病理組織では, 真皮上層から下層の血管に白血球破砕性血管炎を認めた。病理組織を検討した報告は我々が調べ得た限り本邦で2例のみであった。我々は, 皮膚生検で白血球破砕性血管炎を認め, 腎機能障害を併発した日本紅斑熱の1例を経験したので, 若干の文献的考察を加え報告した。
NAKANO, Michiyo, INAFUKU, Kazuhiro
openaire   +1 more source

A case of acute renal dysfunction and multiorgan dysfunction caused by Rickettsia japonica infection

IDCases
This article reports a case of acute renal dysfunction and multi-organ dysfunction syndrome caused by Rickettsia japonica infection. The patient, a 79-year-old male, presented with unexplained fever, fatigue, anorexia, vomiting, and chest tightness ...
Qingyong Zhang, Zhongqiu Teng, Ping Gong
doaj   +1 more source